lncNEAT1通过ceRNA网络调控细胞氧化应激损伤的机制与研究进展

doi:10.6040/j.issn.1671-7554.0.2025.1132

Abstract

Abstract: Cellular oxidative stress plays critical roles in regulating key pathophysiological processes, including cell proliferation, inflammatory responses, and programmed cell death(e.g., apoptosis, ferroptosis, and autophagy). Recent studies have revealed that the long non-coding RNA nuclear paraspeckle assembly transcript 1(lncNEAT1)serves a pivotal function in cellular stress responses. The expression of lncNEAT1 is induced under oxidative stress; in turn, it modulates oxidative stress levels via molecular mechanisms such as the competitive endogenous RNA(ceRNA)pathway. This bidirectional regulatory interplay constitutes a pivotal link in disease development and progression. LncNEAT1 exerts a dual role in regulating redox homeostasis, either exacerbating or alleviating effects depending on the cell type and pathological context. This review outlines how oxidative stress regulates lncNEAT1 expression and details the mechanisms by which lncNEAT1 functions as a ceRNA to sponge microRNA(miRNA), thereby modulating oxidative stress and cellular damage. These mechanisms include regulating reactive oxygen species(ROS)production, modulating the activity of key transcription factors(e.g., Nrf2, NF-κB, STAT3), and interfering with glutathione(GSH)synthesis. A deeper insight into the regulatory network between lncNEAT1 and oxidative stress is expected to provide novel strategies for elucidating pathogenesis, identifying diagnostic biomarkers, and developing targeted therapies for oxidative stress-related diseases affecting the cardiovascular, cerebrovascular, nervous, and reproductive systems.

Key words: lncNEAT1, Oxidative stress, Competitive endogenous RNA, Reactive oxygen species, Nuclear factor erythroid 2-related factor 2

CLC Number:

R329.2

ZHANG Hanzhi, CHEN Wen, LIANG Qihui, DING Shengyong, WU Haicui. Research progress on the mechanism of lncNEAT1 in regulating cellular oxidative stress via the ceRNA network[J].Journal of Shandong University (Health Sciences), 2026, 64(7): 100-117.

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Research progress on the mechanism of lncNEAT1 in regulating cellular oxidative stress via the ceRNA network

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