您的位置:山东大学 -> 科技期刊社 -> 《山东大学学报(医学版)》

山东大学学报(医学版)

• 论文 • 上一篇    下一篇

经皮肺穿刺近距离放射治疗肺癌的疗效观察

王静1,李振家2,王显锋2,明德国2,迟翔宇1   

  1. 1. 山东大学山东省立医院呼吸科, 山东 济南 250021;2. 山东省医学影像学研究所, 山东 济南 250021
  • 收稿日期:2006-03-29 修回日期:1900-01-01 出版日期:2006-10-24 发布日期:2006-10-24
  • 通讯作者: 王静

Brachytherapy by CTguided percutaneous paracentesis implantation of iodine125 seeds for lung cancer

WANG Jing,LI Zhen-jia,WANG Xian-feng,MING De-guo,CHI Xiang-yu   

  1. 1. Department of Respiratory Diseases, Shandong Provincial Hospital, Shandong, University, Jinan 250021, Shandong, China; 2. Shandong Institute of Medical Imaging, Jinan 250021, Shandong, China
  • Received:2006-03-29 Revised:1900-01-01 Online:2006-10-24 Published:2006-10-24

摘要: 目的:探讨CT导向下经皮肺穿刺125I粒子近距离放疗对肺癌的近期疗效。方法:对53例肺癌患者在CT导向下经皮肺穿刺,瘤体内植入125I粒子。观察手术前后局部肿瘤大小、血常规、肝肾功能及免疫指标的变化。结果:对62个病灶行81次穿刺,术后1、2、3、6个月原发部位肿瘤治疗有效率分别为33.87%(21/62)、51.61%(32/62)、91.94%(57/62)、95.16%(59/62)。外周血常规、肝肾功能、免疫功能等指标手术前后无明显变化。5例出现气胸(6.17%),9例发生咳血(11.11%)。植入后第6个月2例患者出现粒子丢失。结论:CT导向下经皮肺穿刺125I粒子近距离放疗对肺癌局部控制率高,对血常规、肝肾功能、免疫功能无明显影响,是一种疗效确切、安全简便的肿瘤微创治疗技术。

关键词: 近距离放疗, 肺肿瘤 , 碘125

Abstract: To explore the clinical value of 125Methods: Implantation of iodine125 seeds with implanting needle (18gauge) by optical navigating system was carried out in fiftythree patients with lung cancer. After operation, the size of tumors and the changes of blood were observed. Results: The fiftythree patients, with sixtytwo focuses, were given eightyone punctures and observed for more than six months. Twelve of the patients were implanted again. The response rate of one, two, three and six months after operation was 33.87%(21/62), 51.61%(32/62),91.94%(57/62) and 95.16%(59/62) respectively. There were no significant changes in peripheral blood cells, liver functions, renal functions, T cell subgroups and the activity of natural killer cells after operation. Pneumothorax and hemoptysis were seen in 5(6.17%,5/81) and 9 (11.11%,9/81) patients respectively. Conclusion: Brachytherapy by CTguided percutaneous paracentesis implantation of iodine125 seeds is effective and safe for the treatment of lung cancer. The complication is rare and easy to treat.

Key words: Iodine125, Brachytherapy, Lung neoplasms

[1] 韩明勇,于晓黎,曾放平,谢兵,芦兰,瞿家权,江璧锋,唐斯晗,谭洁,梁瑾,钟龙辉,王柳,赵宣植. CT引导经皮肺穿刺肿瘤内化疗技术流程[J]. 山东大学学报 (医学版), 2023, 61(11): 11-19.
[2] 王浩,陆建,陈荔,查俊豪,郭金和. CT引导下碘125粒子植入治疗55例腹膜后恶性肿瘤的临床观察[J]. 山东大学学报 (医学版), 2020, 58(6): 65-70.
[3] 王丹鹤,方文岩,张艳萍. 放射性125I粒子治疗肺腺癌伴沉默性骨骼肌转移瘤1例[J]. 山东大学学报 (医学版), 2020, 58(11): 118-120.
[4] 王聪,朱玲,万云焱,姚周虹,李德志,许小婷,徐鹏飞,林殿杰. 重组人血管内皮抑制素不同给药途径联合顺铂对小鼠Lewis肺癌的疗效[J]. 山东大学学报 (医学版), 2019, 57(5): 93-98.
[5] 姜运峰,董晓鹏,赵小刚. PD-1单克隆抗体联合血管内皮抑素在Lewis肺癌小鼠的抗肿瘤效应[J]. 山东大学学报 (医学版), 2018, 56(9): 11-16.
[6] 黄竹青,吴雪韦,任冬梅. 槲寄生中酚类化学成分的分离鉴定及其对A549细胞的增殖抑制活性[J]. 山东大学学报(医学版), 2017, 55(8): 35-41.
[7] 曾奕明,林燕萍. 放射性125I粒子植入局部治疗支气管肺癌[J]. 山东大学学报(医学版), 2017, 55(4): 1-6.
[8] 申文江. 放射性粒子植入的创新性临床研究[J]. 山东大学学报(医学版), 2017, 55(2): 1-3.
[9] 霍彬,王磊,王海涛,霍小东,曹强,王丽丽,臧立,王金焕,郑广钧, 柴树德. 模板联合肋骨钻孔技术辅助放射性粒子植入治疗肺癌的可行性[J]. 山东大学学报(医学版), 2017, 55(2): 26-31.
[10] 韩明勇,霍彬,张颖,林琦,戴建建,徐瑞彩,杨琦,耿宝成,郑广钧,王海涛,霍小东,陈宝明(柴树德,王俊杰审阅). CT联合模板引导放射性粒子植入治疗肺癌技术流程[J]. 山东大学学报(医学版), 2017, 55(2): 14-20.
[11] 李星宇, 梁婧, 李岩. 血管内皮抑素协同肿瘤特异性DC-T细胞的抗肿瘤效应[J]. 山东大学学报(医学版), 2015, 53(7): 19-23.
[12] 贾颖,祖珊珊,郏雁飞,肖东杰,汪运山,马晓丽. CHRNA5基因表达下调对肺癌细胞VEGF表达的影响[J]. 山东大学学报(医学版), 2014, 52(2): 12-15.
[13] 孙越,刘香岚,王群,郭春,石永玉,张利宁. 人TIPE家族新成员TIPE3特异性抗体的鉴定及应用[J]. 山东大学学报(医学版), 2014, 52(1): 5-9.
[14] 祖珊珊1,马晓丽1,2,郏雁飞1,2,赵云3,贾颖1,肖东杰1,2,汪运山1,2. α5-烟碱型乙酰胆碱受体表达下调对肺癌细胞HIF-1α表达的影响[J]. 山东大学学报(医学版), 2013, 51(9): 8-12.
[15] 张林1,张振江2,孟龙1,马伟1,杜贾军1. 恶性局灶性磨玻璃样肺结节的外科治疗[J]. 山东大学学报(医学版), 2013, 51(9): 84-87.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!