山东省儿童新型冠状病毒感染者流行病学及临床特征

doi:10.6040/j.issn.1671-7554.0.2020.335

摘要/Abstract

摘要： 目的分析山东省儿童新型冠状病毒感染者流行病学及临床特征。方法收集 2020年1月26日至2月29日山东省各地区经核酸检测新型冠状病毒核酸阳性的37例患儿病例资料。回顾性分析流行病学史,总结其中21例感染者的临床特征、辅助检查、治疗及转归。结果 37例病例中,发病前2周内有武汉地区旅行史或居住史的12例(32.4%),与已确诊病例有密切接触史的33例(89.2%),有聚集发病现象的31例(83.8%)。21例有临床资料的感染者中,轻型10例(47.6%)、普通型11例(52.4%),无重型及危重型病例。主要首发症状有发热、咳嗽、腹泻。实验室检查中,外周血白细胞总数下降患者占33.3%,其他有降钙素原轻度增高,补体下降,心肌酶谱增高,C-反应蛋白、血沉无变化。CT检查示,52.4%的患儿有典型肺炎表现。治疗以干扰素、克力芝、利巴韦林、奥司他韦及中成药为主。100%转归良好。结论山东省儿童新型冠状病毒感染者多为家庭内密切接触而聚集性发病,临床表现以轻型和普通型为主,存在无症状患者。肺部CT是辅助诊断新型冠状病毒肺炎的重要手段。

关键词: 新型冠状病毒感染者, 山东省, 儿童, 流行病学, 临床特征

Abstract: Objective To explore the epidemiological and clinical characteristics of children infected with SARS-CoV-2 in Shandong Province. Methods A total of 37 children patients diagnosed by novel coronavirus nucleic acid detection positively from January 26 to February 29, 2020 in Shandong Province were collected. The epidemiological history was retrospectively analyzed and the clinical characteristics, laboratory results, treatment and outcome of 21 patients among them were summarized. Results Among the 37 cases, 12 cases(32.4%)had a history of travel or residence in Wuhan within 2 weeks before the onset, 33 cases(89.2%)had a history of contact with confirmed patients and 31 cases(83.8%)had aggregation. Among the 21 patients who had available clinical data, 10 were diagnosed as mild(47.6%), 11 were diagnosed as common(52.4%), and there were no severe or critical types. Common symptoms at onset of illness were fever, cough, and headache. About 33.3% of patients had decreased WBC count. Comparied with normal, the serum level of PCT was increased, C3 and C4 decreased, creatine kinase-MB(CK-MB)increased, CRP and ESR did not change in most of the patients. CT showed that 52.4% of the patients had typical pneumonia. The interferon, lopinavir and ritonavir, ribavirin, oseltamivir and Chinese medicines were the main treatments. All patients went well. Conclusion Most of the children infected with SARS-CoV-2 in Shandong Province were aggregation with families. These children were mainly mild or common types, and even asymptomatic patients. Chest CT remains an important method for diagnosis of children infected with SARS-CoV-2.

Key words: Novel coronavirus infection, Shandong Province, Children, Epidemiological features, Clinical features

中图分类号:

R511

曹爱华,段春红,邱丙平,路苓,李可亮, 刘学工,周志远,孙建华,鞠秀丽. 山东省儿童新型冠状病毒感染者流行病学及临床特征[J]. 山东大学学报 (医学版), 2020, 58(6): 34-40.

CAO Aihua, DUAN Chunhong, QIU Bingping, LU Ling, LI Keliang, LIU Xuegong, ZHOU Zhiyuan, SUN Jianhua, JU Xiuli. Epidemiological and clinical characteristics of children infected with SARS-CoV-2 in Shandong Province[J]. Journal of Shandong University (Health Sciences), 2020, 58(6): 34-40.

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