济南市10例儿童新型冠状病毒肺炎确诊病例流行病学和临床特征

doi:10.6040/j.issn.1671-7554.0.2020.305

摘要/Abstract

摘要： 目的回顾性分析济南市报告的10例儿童新型冠状病毒肺炎确诊病例的流行病学和临床特征。方法依据《新型冠状病毒肺炎诊疗方案(试行第5版)》中新型冠状病毒肺炎诊断标准和临床分型,以济南市截至2020年2月26日报告的所有儿童(年龄<18岁)新型冠状病毒肺炎确诊病例为研究对象,收集儿童确诊病例的流行病学和临床资料,对儿童确诊病例的人口学、流行病学、临床特征进行描述性分析。结果济南市共报告儿童新型冠状病毒肺炎确诊病例10例,男性3例,女性7例。年龄分布包括婴幼儿、学龄前儿童和学龄儿童。10例儿童确诊病例均为家庭内传播病例,在对确诊病例密切接触者主动筛查中发现,父母是其主要的传染来源。患儿发病至确诊的时间间隔最短为0 d,最长为6 d,时间间隔中位数为1.5 d。儿童确诊病例的临床症状为轻型3例和普通型7例,5例患儿首次检出新型冠状病毒核酸阳性时身体无不适症状。截至2月26日,10例儿童COVID-19确诊病例中有6例患儿出院,住院天数中位数为15 d。结论儿童新型冠状病毒肺炎确诊病例以家庭内感染为主,开展密切接触者集中隔离医学观察和主动采样监测对病例的早发现有重要意义。

关键词: 新型冠状病毒肺炎, 儿童, 流行病学, 流行特征, 家庭聚集

Abstract: Objective To analysis the epidemiological and clinical characteristics of 10 children with coronavirus disease(COVID-19)in Jinan City. Methods To collect the information of all the children(<18 years)with COVID-19 in Jinan City by Feb 26, 2020. The diagnosis was based on Chinas “COVID-19 diagnosis and treatment plan(fifth version)”. Data of general information, epidemiological and clinical characteristics were analyzed. Results Ten children with COVID-19 were reported, including 3 males and 7 females. Age distribution included all stages of children. All the 10 confirmed cases of children were family transmitted cases. Parents were the main source of infection in the active sampling and monitoring of close contacts. The shortest time interval from onset to diagnosis was 0 days, the longest was 6 days, and the median time interval was 1.5 days. The clinical symptoms of COVID-19 were mild(3 cases)and common(7 cases). Five children had no symptoms when they were detected the new coronavirus nucleic acid positive for the first time. As of Feb 26, 6 of the 10 confirmed cases were discharged, with a median length of stay was 15 days. Conclusion Family infection is the main source of infection for children. It is important to carry out centralized isolation medical observation and active sampling monitoring of close contacts for early detection of cases.

Key words: Coronavirus disease 2019, Child, Epidemiology, Epidemiological characteristics, Family clustering

中图分类号:

R181.3

杨柳,李战,许华茹,常彩云,刘仲,李传彬,孙湛,景睿,刘铁诚,耿兴义,周敬文. 济南市10例儿童新型冠状病毒肺炎确诊病例流行病学和临床特征[J]. 山东大学学报 (医学版), 2020, 58(4): 36-39.

YANG Liu, LI Zhan, XU Huaru, CHANG Caiyun, LIU Zhong, LI Chuanbin, SUN Zhan, JING Rui, LIU Tiecheng, GENG Xingyi, ZHOU Jingwen. Epidemiological and clinical characteristics of 10 children with coronavirus disease(COVID-19)in Jinan City[J]. Journal of Shandong University (Health Sciences), 2020, 58(4): 36-39.

参考文献

[1] 武汉市卫生健康委员会. 武汉市卫健委关于当前我市肺炎疫情的情况通报[EB/OL].(2019-12-31)[2020-03-14]. http://wjw.wuhan.gov.cn/front/web/showDetail/2019123108989.
[2] World Health Organization. Novel Coronavirus - China[EB/OL].(2020-1-12)[2020-3-14]. https://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/.
[3] Wang C, Hornby PW, Hayden FG, et al. A novel coronavirus outbreak of global health concern[J]. Lancet, 2020, 395(10223): 470-473.
[4] Chan JFW, Yuan S, Kok KH, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster[J]. Lancet, 2020, 395(10223): 514-523.
[5] 中华人民共和国国家卫生健康委员会. 关于印发新型冠状病毒肺炎诊疗方案(试行第5版)的通知[EB/OL].(2020-02-05)[2020-03-14]. http://www.nhc.gov.cn/yzygj/s7653p/202002/3b09b894ac9b4204a79db5b8912d-4440.shtml.
[6] 中华人民共和国国家卫生健康委员会. 国家卫生健康委办公厅关于印发新型冠状病毒肺炎防控方案(第4版)的通知[EB/OL].(2020-02-06)[2020-03-14]. http://www.gov.cn/zhengce/zhengceku/2020-02/07/content_5475813.htm.
[7] 中华预防医学会新型冠状病毒肺炎防控专家组. 新型冠状病毒肺炎流行病学特征的最新认识[J]. 中华流行病学杂志, 2020, 41(2): 139-144. Special Expert Group for Control of the Epidemic of Novel Coronavirus Pneumonia of the Chinese Preventive Medicine Association. An update on the epidemiological characteristics of novel coronavirus pneumonia(COVID-19)[J]. Chinese Journal of Epidemiology, 2020, 41(2): 139-144.
[8] 中国疾病预防控制中心新型冠状病毒肺炎应急响应机制流行病学组. 新型冠状病毒肺炎流行病学特征分析[J]. 中华流行病学杂志, 2020, 41(2): 145-151. Epidemiology Working Group for NCIP Epidemic Response, Chinese Center for Disease Control and Prevention. The epidemiological characteristics of an outbreak of 2019 novel coronavirus disease(COVID-19)in China[J]. Chinese Journal of Epidemiology, 2020, 41(2): 145-151.
[9] Phelan AL, Katz R, Gostin LO. The Novel Coronavirus Origination in Wuhan, China: Challenges for Global Health Governance[J]. JAMA, 2020, 323(8): 709-710.
[10] 方峰, 罗小平. 面对2019新型冠状病毒感染重大疫情:儿科医生的思考[J]. 中华儿科杂志, 2020, 58(2): 81-85. FANG Feng, LUO Xiaoping. Facing the pandemic of 2019 novel coronavirus infections: the pediatric perspectives[J]. Chinese Journal of pediatrics, 2020, 58(2): 81-85.
[11] 张孝国, 马艳, 肖嘉安, 等. 济南地区儿童新型冠状病毒感染的肺炎临床特征[J]. 山东大学学报(医学版), 2020, 58(3): 62-64. ZHANG Xiaoguo, MA Yan, XAIO Jiaan, et al. Clinical characteristics of novel coronavirus pneumonia in children in Jinan[J]. Journal of Shandong University(Health Sciences), 2020, 58(3): 62-64.
[12] Xu X, Chen P, Wang J, et al. Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission[J]. Sci China Life Sci, 2020, 63(3): 457-460.

相关文章 15

[1]	李东梅,边天帅,王晓华,张静,赵炎,孙素芬,牟鸿,许安廷. 儿童前庭神经炎的前庭诱发肌源性电位结果[J]. 山东大学学报 (医学版), 2026, 64(4): 38-43.
[2]	孙红林,管玉强,于培儒,李磊,杜庆霞,丁浩. 支架植入治疗儿童主动脉缩窄并高血压的可行性及近中期疗效[J]. 山东大学学报 (医学版), 2026, 64(4): 58-62.
[3]	况利,徐何雁. 从精准评估到整合干预:儿童青少年心理健康问题诊疗范式的革新与展望[J]. 山东大学学报 (医学版), 2026, 64(3): 10-16.
[4]	李芳华,刘娜,李晓宇,许殿花,王倩. 儿童青少年抑郁障碍患者服药依从性研究进展[J]. 山东大学学报 (医学版), 2026, 64(3): 24-34.
[5]	孙佳丽,王亮,王长凤,张杰,郭磊. Klippel-Trenaunay综合征儿童情绪与行为特征及其影响因素[J]. 山东大学学报 (医学版), 2026, 64(3): 78-82.
[6]	王倩,胡晓婧,王爱青,孙强,孟春燕,李芳华. 儿童青少年抑郁障碍患者非自杀性自伤文献的可视化分析[J]. 山东大学学报 (医学版), 2026, 64(3): 93-107.
[7]	王悦祺,宋东玉,李玉丽,谢昊,张月蓉. 儿童困难问题和亲社会行为在家庭弹性与祖辈隔代教养压力间的中介作用[J]. 山东大学学报 (医学版), 2026, 64(1): 57-64.
[8]	张政,王建伟,杨玉娟,张宇,宋西成. 哮喘儿童2008及2019年免疫球蛋白E变化及相关危险因素[J]. 山东大学学报 (医学版), 2025, 63(7): 32-36.
[9]	丁小满,吕燕,孙嘉文,赵宝添,亓娜,焦海涛. 2019年3月至2024年2月济南市儿童流感样病例中人鼻病毒流行及基因进化特征[J]. 山东大学学报 (医学版), 2025, 63(7): 102-108.
[10]	曹洛菲,王珊珊,王金荣,姜荷云,苗瑜,马光增. 哮喘发作期FeNO升高儿童肺功能舒张试验的特点分析[J]. 山东大学学报 (医学版), 2025, 63(6): 38-44.
[11]	陈绪军, 何国伟. 着力进一步推进动脉桥在我国冠心病冠脉旁路移植术中的应用[J]. 山东大学学报 (医学版), 2025, 63(5): 1-5.
[12]	莫绪明,王庆峰. 冠状动脉旁路移植术在儿童心血管疾病中的应用[J]. 山东大学学报 (医学版), 2025, 63(5): 40-46.
[13]	李玲,闫宇晗,孔清玉,王敏敏,赵海招,赵翠芬. 直立不耐受症状评分及儿茶酚胺与血管迷走性晕厥患儿情绪障碍的相关性[J]. 山东大学学报 (医学版), 2025, 63(5): 71-78.
[14]	王梦园,张春艳,于文文,寇琳娜,王世富. 2018—2021年山东省儿童与成人临床分离真菌的构成与主要菌种的体外抗真菌药物敏感性监测[J]. 山东大学学报 (医学版), 2025, 63(4): 83-93.
[15]	龚蓉,崔乃雪,陈恺悦,赵佳,单瑞洁,张训琪. 体感游戏在儿童癌症幸存者中的应用[J]. 山东大学学报 (医学版), 2025, 63(4): 94-99.

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed