您的位置:山东大学 -> 科技期刊社 -> 《山东大学学报(医学版)》

山东大学学报 (医学版) ›› 2019, Vol. 57 ›› Issue (6): 46-50.doi: 10.6040/j.issn.1671-7554.0.2019.519

• • 上一篇    下一篇

子宫内膜异位症的药物治疗

彭超,周应芳   

  1. 北京大学第一医院妇产科, 北京 100034
  • 发布日期:2022-09-27
  • 通讯作者: 周应芳. E-mail:zhouyf8853@163.com
  • 基金资助:
    国家重点研发计划(2017YFC1001200)

Medical treatment of endometriosis: an update

PENG Chao, ZHOU Yingfang   

  1. Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, China
  • Published:2022-09-27

摘要: 子宫内膜异位症(EMs)是一种慢性、复发性疾病,保守性手术难以治愈,因此,药物治疗具有重要地位,治疗EMs疼痛常用而有效的药物有非甾体类抗炎药(NSAIDs)、口服避孕药、孕激素类药物、内美通或孕三烯酮、促性腺激素释放激素激动剂(GnRH-a)或拮抗剂及中医中药等。术后长期药物维持治疗控制疼痛和预防复发,近年来得到推崇并已经达成中国专家共识。

关键词: 子宫内膜异位症, 药物治疗, 维持治疗, 促性腺激素释放激素激动剂, 促性腺激素释放激素拮抗剂, 孕激素

Abstract: Endometriosis(EMs)is a chronic and recurrent disease, and can hardly be cured by conservative surgery, so the medical treatment is very important. Many drugs have been developed for relieving pain symptoms associated with EMs, such as nonsteroids anti-inflammatory drugs(NSAIDs), conjugated oral contraceptives, progestins, gestrinone, 山 东 大 学 学 报 (医 学 版)57卷6期 -彭超,等.子宫内膜异位症的药物治疗 \=-gonadotropin-releasing hormone-agonists or GnRH-antagonists, and traditional Chinese medicine. Experts consensus has been achieved and published in 2018 in China on long-term maintenance therapy postoperatively to relieve pain and to prevent recurrence of EMs.

Key words: Endometriosis, Medical treatment, Maintenance therapy, Gonadotropin-releasing hormone-agonists, Gonadotropin-releasing hormone-antagonists, Progestins

中图分类号: 

  • R711.71
[1] 中华医学会妇产科学分会子宫内膜异位症协作组. 子宫内膜异位症的诊治指南[J]. 中华妇产科杂志, 2015, 50(3): 161-169.
[2] 周应芳. 子宫内膜异位症患者长期管理的必要性[J]. 中华妇产科杂志, 2017, 52(3): 145-146.
[3] 中华医师协会妇产科医师分会子宫内膜异位症专业委员会,中华医学会妇产科学分会子宫内膜异位症协作组.子宫内膜异位症长期管理中国专家共识[J]. 中华妇产科杂志, 2018, 53(12): 836-841.
[4] Falcone T, Flyckt R. Clinical management of endometriosis[J]. Obstet Gynecol, 2018, 131(3): 557-571.
[5] Singh SS, Suen MW. Surgery for endometriosis: beyond medical therapies[J]. Fertil Steril, 2017, 107(3): 549-554.
[6] Chaichian S, Kabir A, Mehdizadehkashi A, et al. Comparing the efficacy of surgery and medical therapy for pain management in endometriosis: a systematic review and meta-analysis[J]. Pain Physician, 2017, 20(3): 185-195.
[7] Dunselman GA, Vermeulen N, Becker C, et al. ESHRE guideline: management of women with endometriosis[J]. Hum Reprod, 2014, 29(3): 400-412.
[8] Vercellini P, Buggio L, Somigliana E. Role of medical therapy in the management of deep rectovaginal endometriosis[J]. Fertil Steril, 2017, 108(6): 913-930.
[9] Mama ST. Advances in the management of endometriosis in the adolescent[J]. Curr Opin Obstet Gynecol, 2018, 30(5): 326-330.
[10] Kho RM, Andres MP, Borrelli GM, et al. Surgical treatment of different types of endometriosis: comparison of major society guidelines and preferred clinical algorithms[J]. Best Pract Res Clin Obstet Gynaecol, 2018, 51: 102-110. doi:10.1016/j.bpobgyn.2018.01.020.
[11] Vercellini P, Buggio L, Frattaruolo MP, et al. Medical treatment of endometriosis-related pain[J]. Best Pract Res Clin Obstet Gynaecol, 2018, 51: 68-91. doi:10.1016/j.bpobgyn.2018.01.015.
[12] ACOG Committee Opinion No. 760 summary: dysmenorrhea and endometriosis in the adolescent[J]. Obstet Gynecol, 2018, 132(6):1517-1518.
[13] Brown J, Crawford TJ, Allen C, et al. Nonsteroidal anti-inflammatory drugs for pain in women with endometriosis[J]. Cochrane Database Syst Rev, 2017, 1: CD004753. doi:10.1002/14651858.CD004753.pub4.
[14] 程利南, 狄文, 丁岩, 等. 女性避孕方法临床应用的中国专家共识[J]. 中华妇产科杂志, 2018, 53(7): 433-447.
[15] 复方口服避孕药临床应用中国专家共识专家组. 复方口服避孕药临床应用中国专家共识[J]. 中华妇产科杂志, 2015, 50(2): 81-91.
[16] Caruso S, Iraci M, Cianci S, et al. Comparative, open-label prospective study on the quality of life and sexual function of women affected by endometriosis-associated pelvic pain on 2 mg dienogest/30 μg ethinyl estradiol continuous or 21/7 regimen oral contraceptive[J]. J Endocrinol Invest, 2016, 39(8): 923-931.
[17] Buggio L, Somigliana E, Barbara G, et al. Oral and depot progestin therapy for endometriosis: towards a personalized medicine[J]. Expert Opin Pharmacother, 2017, 18(15): 1569-1581.
[18] Bedaiwy MA, Allaire C, Alfaraj S. Long-term medical management of endometriosis with dienogest and with a gonadotropin-releasing hormone agonist and add-back hormone therapy[J]. Fertil Steril, 2017, 107(3): 537-548.
[19] Osuga Y, Fujimoto-Okabe H, Hagino A. Evaluation of the efficacy and safety of dienogest in the treatment of painful symptoms in patients with adenomyosis: a randomized, double-blind, multicenter, placebo-controlled study[J]. Fertil Steril, 2017, 108(4): 673-678.
[20] Andres Mde P, Lopes LA, Baracat EC, et al. Dienogest in the treatment of endometriosis: systematic review[J]. Arch Gynecol Obstet, 2015, 292(3): 523-529.
[21] Dragoman MV, Gaffield ME. The safety of subcutaneously administered depot medroxyprogesterone acetate(104 mg/0.65 mL): a systematic review[J]. Contraception, 2016, 94(3): 202-215.
[22] Carvalho N, Margatho D, Cursino K, et al. Control of endometriosis-associated pain with etonogestrel-releasing contraceptive implant and 52-mg levonorgestrel-releasing intrauterine system: randomized clinical trial[J]. Fertil Steril, 2018, 110(6): 1129-1136.
[23] Kim ML, Cho YJ, Kim MK, et al. The efficacy of long-term maintenance therapy with a levonorgestrel-releasing intrauterine system for prevention of ovarian endometrioma recurrence[J]. Int J Gynaecol Obstet, 2016, 134(3): 256-259.
[24] 郎景和, 冷金花, 王泽华, 等. 促性腺激素释放激素激动剂在子宫内膜异位症和子宫平滑肌瘤治疗中的应用专家意见[J]. 中华妇产科杂志, 2017, 52(2): 77-81.
[25] 郎景和,崔恒,戴毅,等. 2015年子宫内膜异位症的诊治指南专家解读[J]. 中华妇产科杂志, 2017, 52(12): 857-861.
[26] 贾双征, 冷金花, 孙蓬然, 等. 黑升麻提取物对子宫内膜异位症患者GnRH-a治疗期间低雌激素症状及生命质量的影响[J]. 中华妇产科杂志, 2015, 50(9): 692-693.
[27] Taylor HS, Giudice LC, Lessey BA, et al. Treatment of endometriosis-associated pain with elagolix, an oral GnRH antagonist[J]. N Engl J Med, 2017, 377(1): 28-40.
[28] Surrey E, Taylor HS, Giudice L, et al. Long-term outcomes of elagolix in women with endometriosis: results from two extension studies[J]. Obstet Gynecol, 2018, 132(1): 147-160.
[29] Barra F, Grandi G, Tantari M, et al. A comprehensive review of hormonal and biological therapies for endometriosis: latest developments[J]. Expert Opin Biol Ther, 2019, 19(4): 343-360.
[30] Perricos A, Wenzl R. Efficacy of elagolix in the treatment of endometriosis[J]. Expert Opin Pharmacother, 2017, 18(13): 1391-1397.
[31] Vercellini P, Viganò P, Barbara G, et al. Elagolix for endometriosis: all that glitters is not gold[J]. Hum Reprod, 2019, 34(2): 193-199.
[32] Markham A. Relugolix: first global approval[J]. Drugs, 2019, 79(6): 675-679.
[33] 段华, 汪沙, 郝敏, 等. 孕三烯酮使用中不规则子宫出血干预的多中心、随机、平行对照研究[J]. 中华妇产科杂志, 2016, 51(2): 98-102. DUAN Hua, WANG Sha, HAO Min, et al. Research of gestrinone-related abnormal uterine bleeding and the intervention in the treatment: a multi-center, randomized, controlled clinical trial[J]. Chinese Journal of Obstetrics and Gynecology, 2016, 51(2): 98-102.
[34] 周应芳. 子宫腺肌病药物治疗原则及注意事项[J]. 中国实用妇科与产科杂志, 2017, 33(2): 157-160. ZHOU Yingfang. Principles and precautions of medical treatment for adenomyosis of the uterus[J]. Chinese Journal of Practical Gynecology and Obstetrics, 2017, 33(2): 157-160.
[35] Barra F, Scala C, Mais V, et al. Investigational drugs for the treatment of endometriosis, an update on recent developments[J]. Expert Opin Investig Drugs, 2018, 27(5): 445-458.
[1] 樊呈敏,宋静雨,于书彦,毛雪琴. 舒肝解郁胶囊治疗青少年抑郁障碍的研究进展[J]. 山东大学学报 (医学版), 2026, 64(3): 17-23.
[2] 张舒淇,江延姣,印丹. 生殖道微生物与子宫内膜异位症发展之间的联系[J]. 山东大学学报 (医学版), 2025, 63(5): 120-126.
[3] 徐萍,张信美. 子宫内膜异位症疼痛的机制[J]. 山东大学学报 (医学版), 2025, 63(10): 1-7.
[4] 黄艳,周应芳,彭超. 青少年子宫内膜异位症的管理要点和策略[J]. 山东大学学报 (医学版), 2025, 63(10): 8-12.
[5] 薛铭,梁静,凌斌. 各种类型子宫内膜异位症疼痛特点及治疗研究进展[J]. 山东大学学报 (医学版), 2025, 63(10): 13-19.
[6] 赵书睿,赵烨. 围绝经期及绝经后期子宫内膜异位症的诊疗现状[J]. 山东大学学报 (医学版), 2025, 63(10): 20-26.
[7] 梁炎春,严莹,麦华希,姚书忠. 地诺孕素在子宫内膜异位症相关性疼痛中的治疗作用:从基础到临床[J]. 山东大学学报 (医学版), 2025, 63(10): 27-33.
[8] 董向毅,刘昕,刘欣欣,徐亚瑄,赵琳丽,陶国伟. 盆腔深部子宫内膜异位症的超声评价[J]. 山东大学学报 (医学版), 2025, 63(10): 34-42.
[9] 刘振花,连雅囡,米国琳. 子宫内膜异位症疼痛的心理因素及干预措施的研究进展[J]. 山东大学学报 (医学版), 2025, 63(10): 43-51.
[10] 杜煜晗,孙莹,杜惠兰. 红花如意丸对寒凝血瘀型子宫内膜异位症痛经患者疼痛的疗效及机制[J]. 山东大学学报 (医学版), 2025, 63(10): 52-60.
[11] 张丽霞,田一正,吕尚格,张亚男,颜磊. GnRH-a预处理对子宫内膜异位症患者替代方案冻胚移植结局的影响[J]. 山东大学学报 (医学版), 2023, 61(10): 63-68.
[12] 颜磊,岳彩欣,刘懿淳. 子宫内膜异位症的生育力保护[J]. 山东大学学报 (医学版), 2022, 60(9): 31-34.
[13] 彭超,周应芳. 子宫腺肌病的药物治疗进展[J]. 山东大学学报 (医学版), 2022, 60(7): 20-25.
[14] 冷金花, 史精华. 子宫腺肌病的临床表现[J]. 山东大学学报 (医学版), 2022, 60(7): 1-5.
[15] 陈忠绍,褚然,李明宝,张向宁. MRKH综合征相关腹股沟子宫疝修补术后腹壁瘢痕子宫内膜异位症1例报道并文献复习[J]. 山东大学学报 (医学版), 2022, 60(5): 114-117.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!