影响孕产妇下肢深静脉血栓预后的危险因素分析

doi:10.6040/j.issn.1671-7554.0.2021.0482

摘要/Abstract

摘要： 目的通过对孕产妇下肢深静脉血栓(DVT)患者进行预后随访,探讨影响孕产妇DVT预后的危险因素。方法选取2015年12月至2020年1月于山东大学第二医院产科产检并分娩的DVT孕产妇(n=37)的临床资料进行回顾性分析。根据血栓是否消失将其分为血栓完全消失组(n=13)和血栓机化残留组(n=24),采用独立样本t检验、秩和检验(Mann-Whitney U检验)、χ2检验对两组患者的临床特征、实验室指标及静脉血栓栓塞(VTE)危险因素评分进行单因素分析。结果血栓完全消失组D-二聚体为1 340.50(659.00,2 447.75)ng/mL,血栓机化残留组D-二聚体为3 105.00(1 709.50,6 146.00)ng/mL,差异有统计学意义(P=0.009);VTE危险因素评分:血栓完全消失组为(3.31±1.11)分,血栓机化残留组为(4.96±1.94)分,差异有统计学意义(P=0.002);本次妊娠并发子痫前期例数:血栓完全消失组0例(0%),血栓机化残留组6例(25%),差异有统计学意义(P=0.038)。结论 D-二聚体高浓度、 VTE危险因素高评分、并发子痫前期是孕产妇DVT患者血栓机化残留的危险因素。

关键词: 下肢深静脉血栓, D-二聚体, VTE危险因素评分, 预后随访, 危险因素

Abstract: Objective To investigate the risk factors affecting the prognosis of deep vein thrombosis(DVT)in pregnant and parturient women. Methods Clinical data of 37 pregnant women with DVT who underwent obstetric examination and delivered in The Second Hospital of Shandong University during Dec. 2015 and Jan. 2020 were retrospectively analyzed. According to thrombus status, the subjects were divided into two groups: thrombus disappearance group(n=13)and thrombus residue group(n=24). Independent sample t test, rank sum test(Mann-Whitney U test)and χ2 test were used for univariate analysis of clinical characteristics, laboratory indicators and VTE risk factors score of the two groups. Results The D-dimer was 1 340.50(659.00, 2 447.75)ng/mL in the thrombus disappearance group, and 3 105.00(1 709.50, 6 146.00)ng/mL in the thrombus reside group(P=0.009). VTE risk factors score was 3.31±1.11 in the thrombus disappearance group and 4.96±1.94 in the thrombus residue group(P=0.002). The number of cases complicated with preeclampsia during pregnancy was 0 case(0%)in the thrombus disappearance group and 6 cases(25%)in the thrombus residue group(P=0.038). Conclusion High score of VTE risk factors, complicated preeclampsia and high concentration of D-dimer are the risk factors for residual thrombus in pregnant and maternal DVT patients.

Key words: Deep vein thrombosis, D-dimer, VTE risk factors score, Prognosis and follow-up, Risk factors

中图分类号:

R714.25

陈丽宇,肖娟,吕仙忠,段宝敏,洪凡真. 影响孕产妇下肢深静脉血栓预后的危险因素分析[J]. 山东大学学报 (医学版), 2021, 59(7): 38-42.

CHEN Liyu, XIAO Juan, LYU Xianzhong, DUAN Baomin, HONG Fanzhen. Risk factors influencing prognosis of lower extremity deep vein thrombosis in pregnant and parturient women[J]. Journal of Shandong University (Health Sciences), 2021, 59(7): 38-42.

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