体素内不相干运动磁共振成像对糖尿病患者肾脏功能的评价作用

doi:10.6040/j.issn.1671-7554.0.2015.1065

摘要/Abstract

摘要： 目的探讨体素内不相干运动磁共振成像(IVIM-MRI)评价糖尿病患者肾脏功能的价值。方法采用3.0T磁共振分别对20例糖尿病患者(糖尿病组)和正常对照组进行肾脏IVIM扫描,比较两组间及组内皮、髓质的弥散系数(D)、灌注分数(f)、灌注相关弥散系数(D* )间的差异。结果糖尿病组皮质D值及f值大于正常对照组,差异有统计学意义(t=2.187, P=0.035; t=2.334, P=0.025);糖尿病组髓质D值及f值大于正常对照组,但差异无统计学意义(t=1.753, P=0.088; t=0.682, P=0.499);糖尿病组皮、髓质D*值均大于正常对照组,但差异无统计学意义(t=0.088, P=0.93; t=0.592, P=0.557)。同组内皮质与髓质间D值、 f值及D*值差异均有统计学意义(糖尿病组:t=9.64, P=0.002; t=12.163, P=0.001; t=15.993, P=0.001;正常对照组:t=11.228, P=0.001; t=12.055, P=0.001; t=14.708, P=0.001)。结论 IVIM-MRI可无创地评价糖尿病患者肾脏功能,增加了其在临床的应用范围。

关键词: 体素内不相干运动磁共振成像, 糖尿病, 弥散系数, 肾功能, 灌注分数

Abstract: Objective To investigate the value of introvoxel incoherent motion magnetic resonance imaging(IVIM-MRI)in evaluating renal function of diabetes mellitus. Methods IVIM-MRI was performed in 20 cases of diabetes mellitus(diabetic group)and 20 healthy controls(control group)using 3.0T MR system. The differences of diffusion coefficient(D), perfusion fraction(f), and pseudodiffusion coefficient(D*)were compared. Results D and f values of renal cortex of the diabetic group were significantly higher than those of the control group(t=2.187, P=0.035; t=2.334, P=0.025). D and f values of renal medulla of the diabetic group were higher than those of control group, but with no significant differences(t=1.753, P=0.088; t=0.682, P=0.499). D* values of renal medulla and cortex of the diabetic group were higher than those of the control group, but without significant differences(t=0.088, P=0.93; t=0.592, P=0.557). D, f, D* values of renal medulla were significantly different from those of renal cortex in both diabetic and control groups(diabetes mellitus group t=9.64, P=0.002; t=12.163, P=0.001; t=15.993, P=0.001; control group t=11.228, P=0.001; t=12.055, P=0.001; t=14.708, P=0.001). Conclusion Introvoxel incoherent motion MR imaging can evaluate the renal function of diabetic patients non-invasively.

Key words: Diabetes mellitus, Renal function, Perfusion fraction, Introvoxel incoherent motion MR imaging, Diffusion coefficient

中图分类号:

R587.1

俞璐,刘强. 体素内不相干运动磁共振成像对糖尿病患者肾脏功能的评价作用[J]. 山东大学学报（医学版）, 2016, 54(11): 68-71.

YU Lu, LIU Qiang. Introvoxel incoherent motion MR imaging for the assessment of renal function of diabetes mellitus[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(11): 68-71.

参考文献

[1] Bourillon C, Rahmouni A, Lin C, et al. Intravoxel incoherent motion diffusion-weighted imaging of multiple myeloma lesions: correlation with whole-body dynamic contrast agent-enhanced MR imaging[J]. Radiology, 2015, 277(3):773-783.
[2] Marzi S, Stefanetti L, Sperati F, et al. Relationship between diffusion parameters derived from intravoxel incoherent motion MRI and perfusion measured by dynamic contrast-enhanced MRI of soft tissue tumors[J]. NMR Biomed, 2016, 29(1):6-14.
[3] Pang Y, Turkbey B, Bernardo M, et al. Intravoxel incoherent motion(IVIM)MR imaging for prostate cancer: an evaluation of perfusion fraction and diffusion coefficient derived from different b-value combinations[J]. Magn Reson Med, 2013, 69(2):553-562.
[4] Bokacheva L, Kaplan JB, Giri DD, et al. Intravoxel incoherent motion diffusion-weighted MRI at 3.0 T differentiates malignant breast lesions from benign lesions and breast parenchyma[J]. J Magn Reson Imaging, 2014, 40(4):813-823.
[5] Sumi M, Van Cauteren M, Sumi T, et al. Salivary gland tumors: use of intravoxel incoherent motion MR imaging for assessment of diffusion and perfusion for the differentiation of benign from malignant tumors[J]. Radiology, 2012, 263(3):770-777.
[6] Rheinheimer S, Stieltjes B, Schneider F, et al. Investigation of renal lesions by diffusion-weighted magnetic resonance imaging applying intravoxel incoherent motion-derived parameters-initial experience[J]. Eur J Radiol, 2012, 81(3):310-316.
[7] Gaing B, Sigmund EE, Huang WC, et al. Subtype differentiation of renal tumors using voxel-based histogram analysis of intravoxel incoherent motion parameters[J]. Invest Radiol, 2015, 50(3):144-152.
[ 8] Hennedige T, Koh TS, Hartono S, et al. Intravoxel incoherent imaging of renal fibrosis induced in a murine model of unilateral ureteral obstruction[J]. Magn Reson Imaging, 2015, 33(10):1324-1328.
[9] Lee CH, Yoo KH, Je BK, et al. Using intravoxel incoherent motion MR imaging to evaluate cortical defects in the first episode of upper urinary tract infections: preliminary results[J]. J Magn Reson Imaging, 2014, 40(3):545-551.
[10] Eckerbom P, Hansell P, Bjerner T, et al. Intravoxel incoherent motion MR imaging of the kidney: pilot study[J]. Adv Exp Med Biol, 2013, 765:55-58. doi: 10.1007/978-1-4614-4989-8_8.
[11] Ichikawa S, Motosugi U, Ichikawa T, et al. Intravoxel incoherent motion imaging of the kidney: alterations in diffusion and perfusion in patients with renal dysfunction[J]. Magn Reson Imaging, 2013, 31(3):414-417.
[12] Notohamiprodjo M, Chandarana H, Mikheev A, et al. Combined intravoxel incoherent motion and diffusion tensor imaging of renal diffusion and flow anisotropy[J]. Magn Reson Med, 2015, 73(4):1526-1532.
[13] Doganay S, Kocakoç E, Ciçekçi M, et al. Ability and utility of diffusion-weighted MRI with different b values in the evaluation of benign and malignant renal lesions[J]. Clinical Radiology, 2011, 66(5):420-425.
[14] Notohamiprodjo M, Chandarana H, Mikheev A, et al. Combined intravoxel incoherent motion and diffusion tensor imaging of renal diffusion and flow anisotropy[J]. Magn Reson Med, 2015, 73(4):1526-1532.

相关文章 15

[1]	孟晓梅,郝亚平,王亮,于晓,唐与晓. 血清Isthmin1、Gremlin2水平与2型糖尿病患者视网膜病变的相关性[J]. 山东大学学报 (医学版), 2025, 63(9): 102-107.
[2]	王梦星,薛付忠,杨帆. 基于多模态交叉注意力机制融合的1型糖尿病血糖浓度预测方法[J]. 山东大学学报 (医学版), 2025, 63(8): 41-50.
[3]	申路佳,逯天威,巩伟明,赵岩松,王淑康,袁中尚. 代谢风险评分在2型糖尿病人群心血管结局预测中的应用[J]. 山东大学学报 (医学版), 2025, 63(8): 69-78.
[4]	陈莹莹,王鲁,胡锡峰,朱高培,薛付忠. 基于贝叶斯网络的2型糖尿病患者并发脑卒中风险预测[J]. 山东大学学报 (医学版), 2025, 63(8): 94-102.
[5]	陈绪军, 何国伟. 着力进一步推进动脉桥在我国冠心病冠脉旁路移植术中的应用[J]. 山东大学学报 (医学版), 2025, 63(5): 1-5.
[6]	卢圣勋,邢亚闯,罗俊辉,刘杰,何厚乐,王志强,张娜. 糖尿病患者冠脉旁路移植手术中动脉桥的研究现状[J]. 山东大学学报 (医学版), 2025, 63(5): 33-39.
[7]	杜学识,倪向敏,梁馨予,白倩,朱文艺,王建. 雌马酚对DN的保护作用及潜在靶点[J]. 山东大学学报 (医学版), 2024, 62(8): 49-58.
[8]	许沛晨,李晓博,庄向华,娄能俊,吕丽,周玲雁,牟亚朋,宋玉文,陈诗鸿. 儿童Alstrom综合征2例并文献复习[J]. 山东大学学报 (医学版), 2024, 62(3): 107-111.
[9]	王璐瑶,胡晓琳,孙佩,董振华,逄曙光. 青年合并骨质疏松的Gitelman综合征1例[J]. 山东大学学报 (医学版), 2024, 62(2): 120-124.
[10]	林晓倩,封茂燕,牟正. 二肽基肽酶-4抑制剂的药学特点及临床应用[J]. 山东大学学报 (医学版), 2024, 62(12): 43-48.
[11]	于丹凤,曹娟,于世佳,杜鲁涛,侯新国. 电化学发光法与液相色谱-串联质谱法评估糖尿病患者维生素D缺乏程度的效能比较与界值确定[J]. 山东大学学报 (医学版), 2023, 61(7): 90-95.
[12]	李金泉,高美芳,闫飞,董明. 136例2型糖尿病患者肌肉痉挛的发生频率及危险因素[J]. 山东大学学报 (医学版), 2023, 61(5): 20-24.
[13]	张天鑫,张婷,黄鑫,韩佳沂,王淑康. 氨基酸与2型糖尿病因果关系的孟德尔随机化分析[J]. 山东大学学报 (医学版), 2023, 61(5): 102-107.
[14]	黄珊,娄能俊,韩晓琳,梁中昊,华梦羽,庄向华,陈诗鸿. 高糖环境下Lipin1对神经元代谢组学的影响[J]. 山东大学学报 (医学版), 2023, 61(2): 1-8.
[15]	包瑾瑾,刘庆燕,孙甜甜,陈青,刘佳. 糖尿病相关抗体阳性合并MODY14相关APPL1基因突变1例[J]. 山东大学学报 (医学版), 2023, 61(12): 113-118.

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed