关键词: 淋巴结, 血管生成因子, 肺肿瘤

Abstract: To investigate the relationship among vascular endothelial growth factor-C, (VEGF-C), VEGF-D, microlymphatic vessel density (MLVD) and lymph node metastasis in lung adenocarcinoma, and to explore the mechanism of cancerous peripheral tissue lymphatic vessels. Methods The expressions of VEGF-C and VEGF-D mRNA were determined by the semi-quantitative reverse transcriptase-polymerase chain reaction method and the expressions of VEGF-C, VEGF-D and MLVD were determined in the center of the tumors and peripheral tissues by means of immunohistochemistry in 48 cases of lung adenocarcinoma. ResultsExpressions of VEGF-C and VEGF-D mRNA were higher in lung cancer than in normal lung tissues, positive ratio of VEGF-C and VEGF-D was 70.8%(34/48) and 58.3(28/48). The expressions of VEGF-C and VEGF-D in cancerous peripheral tissues were significantly higher than those in the center of the tumors. The MLVD and positive lymph node metastasis in the positive VEGF-C or VEGF-D group were higher than those in the negative group. Conclusion The expression of VEGF-C and VEGF-D can induce lymphangiogenesis of lung adenocarcinoma and lymph metastasis.

Key words: Lung neoplasms, Angiogenesis factor, Lymph nodes