人工肝对猪暴发性肝衰竭模型细胞因子动态变化的影响

山东大学学报(医学版)

人工肝对猪暴发性肝衰竭模型细胞因子动态变化的影响

田军¹，耿丽娜¹，李亚明²，李恩刚¹，崔先泉¹

1．山东大学齐鲁医院血液净化中心，济南 250012； 2．北京佑安医院人工肝治疗中心，北京 100054

收稿日期:2007-03-17 修回日期:1900-01-01 出版日期:2008-05-16 发布日期:2008-05-16
通讯作者: 田军

Effect of artificial liver on serum cytokine in the fulminant hepatic failure model in pigs

TIAN Jun¹,　GENG Li-na¹,　LI Ya-ming²,　LI En-gang¹,　CUI Xian-quan¹

1. Department of Blood Purification, Qilu Hospital of Shandong University, Jinan 250012, China;2. Treatment Center of Artificial Liver, Beijing You′an Hospital, Beijing 100054, China

Received:2007-03-17 Revised:1900-01-01 Online:2008-05-16 Published:2008-05-16
Contact: TIAN Jun

摘要/Abstract

摘要： 目的研究血浆置换联合血液滤过对猪暴发性肝衰竭模型肿瘤坏死因子（TNF-α）,白细胞介素-6（IL-6）,白细胞介素-1β（IL-1β）动态变化的影响。方法应用D-氨基半乳糖建立猪暴发性肝衰竭模型，随机分为对照组和治疗组，治疗组24h和48h分别给予血浆置换联合血液滤过治疗，检测两组细胞因子的动态变化。结果对照组和治疗组的TNF-α、IL-6、 IL-1β均随时间延长明显升高，与建立模型前比较，差异有统计学意义（P＜0.05），人工肝治疗前各时间点两组比较无统计学差异（P＞0.05），但经血浆置换联合血液滤过治疗后，治疗组的血清细胞因子升高趋势减缓，与对照组相比，差异有统计学意义（P＜0.05）。结论早期、足量的组合非生物人工肝能有效清除TNF-α,IL-6,IL-1β，为暴发性肝衰竭时肝细胞的再生或者桥接肝脏移植赢得时间。

关键词: 猪, 细胞因子, 动物模型, 人工肝, 肝衰竭

Abstract: To investigate the effects of plasma exchange (PE) combined with hemofiltration (HF) on the dynamic changes of serum cytokine TNF-α, IL-6 and IL-1β. MethodsThe fulminant liver failure animal models of mini-pigs were established with D-galactosamine, and they were randomly divided into the treatment group and the control group. After 24 hours and 48 hours, the treatment group received plasma exchange (PE) plus hemofiltration (HF) twice. The differences of cytokines in two groups were determined. ResultsThe cytokines TNF-α, IL-6 and IL-1β significantly increased with time in both the control group and the treatment group. There were no significant differences between the two groups before artificial liver therapy. However, after plasma exchange (PE) plus hemofiltration (HF), the change tendency of serum cytokines of the treatment group was significantly different from that of the control group. ConclusionEarly and enough combined non-bio-artificial liver(PE plus HF) can efficiently clear TNF-α, IL-6 and IL-1β and earn time for liver regeneration or liver transplantation.

Key words: Liver failure, Artificial liver, Cytokine, Animal model, Minipig

中图分类号:

Ｒ659.3

田军,耿丽娜,李亚明,李恩刚,崔先泉 . 人工肝对猪暴发性肝衰竭模型细胞因子动态变化的影响[J]. 山东大学学报(医学版), 2008, 46(5): 475-477.

TIAN Jun,GENG Li-na,LI Ya-ming,LI En-gang,CUI Xian-quan. Effect of artificial liver on serum cytokine in the fulminant hepatic failure model in pigs[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(5): 475-477.

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