音乐疗法对心理应激兔血脂的影响及机制

山东大学学报(医学版)

音乐疗法对心理应激兔血脂的影响及机制

赵莉，孙萍，燕芳芳，刘艳，赵玉霞

（教育部和卫生部心血管重构和功能研究重点实验室山东大学齐鲁医院中医科，济南 250012）

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2009-01-16 发布日期:2009-01-16
通讯作者: 赵玉霞

Effect and possible mechanism of music therapy for concentration of
serum lipids in psychological stress rabbit models

ZHAO Li, SUN Ping, YAN Fangfang, LIU Yan, ZHAO Yuxia

(Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and
Chinese Ministry of Public Health, Department of Traditional Chinese Medicine,
Qilu Hospital of Shandong University, Jinan 250012, China)

Received:1900-01-01 Revised:1900-01-01 Online:2009-01-16 Published:2009-01-16
Contact: ZHAO Yuxia

摘要/Abstract

摘要： 目的观察音乐疗法对心理应激兔血脂水平的影响，并探讨其可能机制。方法将40只雄性新西兰大白兔随机分为对照组(A组，n=10)，音乐组(B组，n=10)，心理应激组(C组，n=10)和心理应激加音乐组(D组，n=10)。B组每天听小提琴协奏曲—梁山伯与祝英台4?h，C组进行慢性不可预见性心理应激，D组除进行慢性不可预见性心理应激外，每天听小提琴协奏曲—梁山伯与祝英台4?h。试验周期为8周。于试验前后测定血清中总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDLc)、高密度脂蛋白（HDLc）、HDLc/LDLc值以及神经肽Y（NPY）的浓度，分离腹主动脉进行油红O染色，观察脂质含量。结果与C组相比，D组的LDLC、TC和TG浓度均显著降低（P＜0.05），而HDLc/LDLc显著升高（P＜0.05），油红O脂质染色面积显著小于C组（P＜0.05），NPY浓度和血脂浓度亦明显低于C组（P＜0.05）。结论音乐疗法可以明显缓解长期慢性心理应激所导致的血脂代谢紊乱，其降脂作用可能与抑制NPY的释放有关。

关键词: 音乐疗法, 脂质, 神经肽Y, 兔

Abstract: To observe the effects of music therapy for the concentration of serum lipids of psychological stress rabbit models and to investigate its possible mechanism. MethodsForty New Zealand male rabbits were randomly divided into 4 groups: the control group (A), the music group (B), the psychological stress group (C) and the psychological stress plus music group (D). Group B was given music 4 hours each day. Group C was given psychological stress. Group D was given music 4 hours and psychological stress each day. The experiment period was 8 weeks. The concentrations of total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDLc), and neuropeptide Y (NPY) were determined at the beginning and end of the experiment, and HDL/LDL was calculated. At the end of the experiment, abdominal aorta of the rabbits was taken out and dyed with rathonum red O which was used to examine the degree of lipidoses in vessel walls. ResultsThe concentration of TC, TG, LDL, HDL, NPY and HDL/LDL was significantly different between group A and group C (P＜0.05) and between group C and group D (P＜0.05), the quantity of lipidoses in the vessel walls of group D was obviously less than that of group C. ConclusionsMusic therapy can alleviate increased serum lipids induced by chronic psychological stress, and the mechanism might relate to music controlling NPY secretion.

Key words: Music therapy, Lipids, Neuropeptide Y, Rabbits

中图分类号:

R543.12

赵莉，孙萍，燕芳芳，刘艳，赵玉霞 . 音乐疗法对心理应激兔血脂的影响及机制
[J]. 山东大学学报(医学版), 2009, 47(01): 15-18.

ZHAO Li, SUN Ping, YAN Fangfang, LIU Yan, ZHAO Yuxia
. Effect and possible mechanism of music therapy for concentration of
serum lipids in psychological stress rabbit models[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2009, 47(01): 15-18.

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