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山东大学学报 (医学版) ›› 2020, Vol. 1 ›› Issue (8): 5-9, 21.doi: 10.6040/j.issn.1671-7554.0.2020.0606

• 脑科学与类脑智能研究专题 • 上一篇    下一篇

当代脑计划研究进展

李新钢1,2,*(),张鑫1,2,陈安静1,2   

  1. 1. 山东大学齐鲁医院神经外科,山东大学脑与类脑科学研究院,山东 济南 250012
    2. 山东省脑功能重构重点实验室,山东 济南 250012
  • 收稿日期:2020-04-15 出版日期:2020-08-07 发布日期:2020-08-07
  • 通讯作者: 李新钢 E-mail:lixg@sdu.edu.cn
  • 作者简介:李新钢,男,医学博士,主任医师,山东大学二级教授,博士研究生导师,“泰山学者”特聘专家,卫生部和山东省有突出贡献的中青年专家。现任山东大学脑与类脑科学研究院院长、山东省脑科学研究所所长、山东省神经系统疾病防治工程技术研究中心主任、山东省脑功能重构重点实验室主任。兼任中华医学会神经外科学分会副主任委员、中国医师协会神经外科医师分会副会长、中国医师协会内镜医师分会副会长。从事神经外科医疗、教学和科研工作37年,开展了多项疑难危重病症的治疗抢救工作,在国内较早开展了神经内镜手术,在脑肿瘤的基础与临床、颅脑外伤和脑血管病的综合诊疗、功能与立体定向神经外科等领域积累了丰富的经验。曾获山东省科技进步一、二、三等奖和中华医学科技三等奖等19项奖励。在国内外学术期刊上发表论文219篇,其中SCI收录104篇;主编和参编各类著作18部。已培养硕士研究生45人,博士研究生41人,博士后8人。被评为全国优秀科技工作者、2018年全国优秀医院院长,曾获得中国神经外科医师最高奖“王忠诚中国神经外科医师年度学术奖”。被山东省人民政府记二等功3次、三等功2次。是山东省“富民兴鲁”劳动奖章获得者、首批山东省卫生系统杰出学科带头人、山东省医学领军人才。
  • 基金资助:
    山东省泰山学者人才工程(ts20110814);山东省泰山学者人才工程(tsqn201909173);中国博士后基金(2018M642666)

The latest advances in human brain projects

Xingang LI1,2,*(),Xin ZHANG1,2,Anjing CHEN1,2   

  1. 1. Department of Neurosurgery, Qilu Hospital of Shandong University and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan 250012, Shandong, China
    2. Shandong Key Laboratory of Brain Function Remodeling, Jinan 250012, Shandong, China
  • Received:2020-04-15 Online:2020-08-07 Published:2020-08-07
  • Contact: Xingang LI E-mail:lixg@sdu.edu.cn

摘要:

科技的进步让人们对大到宇宙小到微观粒子的世界有深入的认识,但是人类对自身大脑的精细结构和运行机制的了解甚少。为此,多个国家和地区纷纷提出并开展“脑研究计划”,简称“脑计划”,以提高对人类大脑的认知,并寻求治疗神经及精神系统疾病的方法。本文对近年来欧盟、美国、日本及我国开展的“脑计划”进行综述,分别介绍各个国家和地区“脑计划”的研究方向及取得的突破性成果,介绍正在开展的“齐鲁脑计划”。“脑计划”的开展有利于推动人工智能等相关学科进步和经济社会发展,未来“脑计划”的实施需要更深入的国际合作。

关键词: 脑计划, 脑与类脑科学, 脑功能重构, 脑疾病, 人工智能技术

Abstract:

With the rapid development of modern technology, we have extended in-depth knowledge of the surrounding world from both macro and micro perspectives. However, we know very little about the fine structure and operation mechanism of human brain. Therefore, many countries and regions have proposed and launched human brain projects to deepen our understanding of human brain and to develop novel treatment for the nervous and psychiatric system related disorders. This paper reviews the human brain projects implemented by the European Union, the United States, Japan and China in recent years, and introduce the key research directions and breakthroughs. We will also proudly introduce the "Qilu Brain Project" carried out by our institute and briefly present our project progress. The implementation of human brain projects is conducive to promoting the progress of artificial intelligence and other related disciplines as well as economic and social development and needs more in-depth international cooperation.

Key words: Human brain project, Brain and brain-inspired science, Brain function remodeling, Brain diseases, Artificial intelligence technology

中图分类号: 

  • R-1
1 White JG , Southgate E , Thomson JN , et al. The structure of the nervous system of the nematode caenorhabditis elegans[J]. Philos Trans R Soc Lond B Biol Sci, 1986, 314 (1165): 1- 340.
doi: 10.1098/rstb.1986.0056
2 Azevedo FA , Carvalho LR , Grinberg LT , et al. Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain[J]. J Comp Neurol, 2009, 513 (5): 532- 541.
doi: 10.1002/cne.21974
3 Amunts K , Ebell C , Muller J , et al. The human brain project: creating a European research infrastructure to decode the human brain[J]. Neuron, 2016, 92 (3): 574- 581.
doi: 10.1016/j.neuron.2016.10.046
4 Er? C , Gewaltig MO , Keller D , et al. A cell atlas for the mouse brain[J]. Front Neuroinform, 2018, 12: 84.
doi: 10.3389/fninf.2018.00084
5 Takahashi N , Oertner TG , Hegemann P , et al. Active cortical dendrites modulate perception[J]. Science, 2016, 354 (6319): 1587- 1590.
doi: 10.1126/science.aah6066
6 Bos JJ , Vinck M , van Mourik-Donga LA , et al. Perirhinal firing patterns are sustained across large spatial segments of the task environment[J]. Nature Commun, 2017, 8: 15602.
doi: 10.1038/ncomms15602
7 Gentile F , van Atteveldt N , De Martino F , et al. Approaching the ground truth: revealing the functional organization of human multisensory STC using ultra-high field fMRI[J]. J Neurosci, 2017, 37 (42): 10104- 10113.
doi: 10.1523/JNEUROSCI.0146-17.2017
8 Storm JF , Boly M , Casali AG , et al. Consciousness regained: disentangling mechanisms, brain systems, and behavioral responses[J]. J Neurosci, 2017, 37 (45): 10882- 10893.
doi: 10.1523/JNEUROSCI.1838-17.2017
9 Amunts K , Knoll AC , Lippert T , et al. The human brain project—synergy between neuroscience, computing, informatics, and brain-inspired technologies[J]. PLoS Biol, 2019, 17 (7): e3000344.
doi: 10.1371/journal.pbio.3000344
10 Marcus D , Harwell J , Olsen T , et al. Informatics and data mining tools and strategies for the human connectome project[J]. Front Neuroinformatics, 2011, 5: 4.
doi: 10.3389/fninf.2011.00004
11 Mott MC , Gordon JA , Koroshetz WJ . The NIH BRAIN Initiative: Advancing neurotechnologies, integrating disciplines[J]. PLoS Biol, 2018, 16 (11): e3000066.
doi: 10.1371/journal.pbio.3000066
12 Yan H , Choe HS , Nam SW , et al. Programmable nanowire circuits for nanoprocessors[J]. Nature, 2011, 470 (7333): 240- 244.
doi: 10.1038/nature09749
13 Cook SJ , Jarrell TA , Brittin CA , et al. Whole-animal connectomes of both Caenorhabditis elegans sexes[J]. Nature, 2019, 571 (7763): 63- 71.
doi: 10.1038/s41586-019-1352-7
14 Okano H , Mitra P . Brain-mapping projects using the common marmoset[J]. Neurosci Res, 2015, 93: 3- 7.
doi: 10.1016/j.neures.2014.08.014
15 Sadato N , Morita K , Kasai K , et al. Neuroethical issues of the brain/MINDS project of Japan[J]. Neuron, 2019, 101 (3): 385- 389.
doi: 10.1016/j.neuron.2019.01.006
16 Woodward A , Hashikawa T , Maeda M , et al. The Brain/MINDS 3D digital marmoset brain atlas[J]. Sci Data, 2018, 5: 180009.
doi: 10.1038/sdata.2018.9
17 Koshiyama D , Fukunaga M , Okada N , et al. White matter microstructural alterations across four major psychiatric disorders: mega-analysis study in 2937 individuals[J]. Mol Psychiatry, 2020, 25 (4): 883- 895.
doi: 10.1038/s41380-019-0553-7
18 蒲慕明. 脑科学的未来[J]. 心理学通讯, 2019, 2 (2): 80- 83.
POO Muming . The future of brain science[J]. Psychological Communications, 2019, 2 (2): 80- 83.
19 Wang Y , Yin J , Wang G , et al. Responsibility and sustainability in brain science, technology, and neuroethics in China—a culture-oriented perspective[J]. Neuron, 2019, 101 (3): 375- 379.
doi: 10.1016/j.neuron.2019.01.023
20 宗伟健, 吴润龙, 李明立, 等. 新一代微型双光子荧光显微镜[J]. 前沿科学, 2018, 12 (1): 60- 65.
ZONG Weijian , WU Runlong , LI Mingli , et al. A new generation miniature two-photon fluorescence microscope[J]. Frontier Science, 2018, 12 (1): 60- 65.
21 Gong H , Xu D , Yuan J , et al. High-throughput dual-colour precision imaging for brain-wide connectome with cytoarchitectonic landmarks at the cellular level[J]. Nat Commun, 2016, 7: 12142.
doi: 10.1038/ncomms12142.NatCommun,2016,7:12142
22 Fan J , Suo J , Wu J , et al. Video-rate imaging of biological dynamics at centimetre scale and micrometre resolution[J]. Nature Photonics, 2019, 13 (11): 809- 816.
doi: 10.1038/s41566-019-0474-7
23 Zhong S , Zhang S , Fan X , et al. A single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex[J]. Nature, 2018, 555 (7697): 524- 528.
doi: 10.1038/nature25980
24 Sun Q , Li X , Ren M , et al. A whole-brain map of long-range inputs to GABAergic interneurons in the mouse medial prefrontal cortex[J]. Nat Neurosci, 2019, 22 (8): 1357- 1370.
doi: 10.1038/s41593-019-0429-9
25 Wang S , Zhao Y , Yan C . Reversible encephalopathy caused by an inborn error of cobalamin metabolism[J]. Lancet, 2019, 393 (10172): e29.
doi: 10.1016/S0140-6736(19)30043-1
26 Han M , Wang S , Fritah S , et al. Interfering with long non-coding RNA MIR22HG processing inhibits glioblastoma progression through suppression of Wnt/β-catenin signaling[J]. Brain, 2020, 143 (2): 512- 530.
27 Wang J , Qi Q , Zhou W , et al. Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy[J]. Autophagy, 2018, 14 (11): 2007- 2022.
doi: 10.1080/15548627.2018.1501133
28 Han MZ , Huang B , Ni SL , et al. A validated prognostic nomogram for patients with newly diagnosed lower-grade gliomas in a large-scale Asian cohort[J]. Neuro Oncol, 2020, 22 (5): 729- 732.
doi: 10.1093/neuonc/noaa027
29 Han M , Wang S , Yang N , et al. Therapeutic implications of altered cholesterol homeostasis mediated by loss of CYP46A1 in human glioblastoma[J]. EMBO Mol Med, 2020, 12 (1): e10924.
doi: 10.15252/emmm.201910924
30 Ji J , Xu R , Ding K , et al. Long noncoding RNA SChLAP1 forms a growth-promoting complex with HNRNPL in human glioblastoma through stabilization of ACTN4 and activation of NF-κB signaling[J]. Clin Cancer Res, 2019, 25 (22): 6868- 6881.
doi: 10.1158/1078-0432.CCR-19-0747
31 王亚, 李永欣, 黄文华. 人类脑计划的研究进展[J]. 中国医学物理学杂志, 2016, 33 (3): 109- 112.
WANG Ya , LI Yongxin , HUANG Wenhua . Progress of human brain science research program[J]. Medical Innovation of China, 2016, 33 (3): 109- 112.
32 李萍萍, 马涛, 张鑫, 等. 各国脑计划实施特点对我国脑科学创新的启示[J]. 同济大学学报(医学版), 2019, 40 (4): 397- 401.
LI Pingping , MA Tao , ZHANG Xin , et al. Enlightenment for China's brain science innovation from global brain projects[J]. Journal of Tongji University (Medical Science), 2019, 40 (4): 397- 401.
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