十字花科蔬菜摄入量与肾细胞癌罹患风险的Meta分析

doi:10.6040/j.issn.1671-7554.0.2014.156

摘要/Abstract

摘要： 目的应用Meta分析方法定量评价十字花科蔬菜（CV）摄入量与肾细胞癌（RCC）罹患风险之间的关系。方法制定检索策略和文献的纳入排除标准，系统检索ProQuest、Web of Science、EMBASE和PUBMED数据库1966年1月至2013年12月间的文献。使用Stata 11.0软件应用随机效应模型和固定效应模型估计合并相对风险RR和相应的95%置信区间（CI）。通过Meta回归探讨异质性的潜在来源。同时应用亚组分析、累积Meta分析和敏感性分析。结果共12篇文献（6篇队列研究和6篇病例对照研究）符合纳入标准，1 228 518例研究对象（包括5 773例RCC病例）。文献汇总结果显示，CV摄入量与RCC罹患风险间的关联性差异有统计学意义[RR=0.81， 95%CI（0.72～0.91）]。亚组分析结果显示，美国人群中，CV摄入量与低RCC罹患风险明显相关[RR=0.77， 95%CI （0.70～0.86）]；欧洲人群中，CV摄入量与RCC罹患风险无明显的相关性[RR=0.87， 95%CI （0.71～1.07）]。结论 Meta分析的结果表明，美国人群摄入较高剂量的CV对RCC具有保护作用。

关键词: 肿瘤风险, 十字花科蔬菜, Meta分析, 肾细胞癌

Abstract: Objective To evaluate the association between cruciferous vegetables (CV) consumption and the risk of renal cell carcinoma (RCC). Methods After the retrieval strategy and criteria for inclusion and exclusion were formulated, databases of ProQuest, Web of Science, EMBASE and PUBMED were searched for literatures publicized during Jan. 1966 to Dec. 2013. Pooled relative risks (RR) and the corresponding 95% confidence intervals (CI) were estimated by random-effect and fixed-effect models. Meta-regression was used to detect potential sources of heterogeneity. Subgroup analyses, cumulative meta-analysis and sensitivity analysis were also conducted. Results A total of 12 studies (6 case-control, 6 cohorts) were included in the analysis, involving 1 228 518 participants (5 773 RCC cases). An obvious negative correlation was found between CV and RCC risk [RR=0.81, 95% CI (0.72-0.91)]. In subgroup analyses, CV was obviously related to lower RCC risk among studies carried out in America [RR=0.77, 95%CI (0.70-0.86)]; nevertheless, CV had no obvious correlation with RCC risk among studies carried out in Europe [RR=0.87, 95%CI (0.71-1.07)]. Conclusion The results of the present Meta-analysis indicated that high consumption of CV is negatively correlated with RCC risk in Americans.

Key words: Cancer risk, Meta-analysis, Renal cell carcinoma, Cruciferous vegetables

中图分类号:

R692

赵龙, 关广聚. 十字花科蔬菜摄入量与肾细胞癌罹患风险的Meta分析[J]. 山东大学学报（医学版）, 2014, 52(7): 82-89.

ZHAO Long, GUAN Guangju. Meta-analysis for consumption of cruciferous vegetables and the morbidity risk of renal cell carcinoma[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(7): 82-89.

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