关键词: 姜黄素, 糖尿病, 大鼠,Wistar, 肾脏

Abstract: To explore the effect of curcumin on the structure and function of the kidney in diabetic rats. MethodsDiabetes was induced by a single intraperitoneal injection of streptozoticin(STZ) to male Wistar rats at a dose of 60?mg/kg body weight and they were randomly divided into two groups: the diabetes group (group D) and the diabetes treated with curcumin group(group DC). A normal control group (group N) was also designed. Curcumin was given at a dose of 200?mg·kg-1·day-1, the other two groups were given the same quantity of CarboxylmethylCellulose(CMC). After a treatment of 8 weeks, renal morphology and blood and urinary biochemistry were evaluated. ResultsLevels of clearance of creatinine(Ccr)， urinary albumin excretion rate(UAER), albumincreatinine ratio(Alb/Cr), mean glomerular area(MGA) and mean glomerular volume(MGV) were all significantly increased in group D as compared with group N(P＜0.01 or P＜0.05) . Large glomeruli，membranes with a thickened glomerular basement, and foot processes confluence into podocytes were found by light microscopy and electron microscopy. All these abnormalities were markedly ameliorated after a curcumin treatment. ConclusionCurcumin is effective in improving renal pathological damage, ameriorating hypertrophy and hyperfiltration, and decreasing the urinary albumin excretion rate(UAER)in diabetic Wistar rats.

Key words: Curcumin, Diabetic mellitus, Wistar rats, Kidney