关键词: 神经管缺陷, 干预性研究, Meta分析, 妇女

Abstract: To estimate the effects of integrated measures on reducing the risks of neural tube defects in Chinese women of childbearing age. MethodsOn the basis of all the relative studies collected, twelve studies with a total of 381561 subjects accepted the interventions。 Intervention areas were divided into two parts: the northern areas and the southern areas. The combined values were evaluated. First, the Woolf method was used for the homogeneity test. If analysis results are homogenous, the Peto method was used to evaluate the combined value, otherwise the DL method was used. Results① Results of the twelve studies were heterogeneous (Q=20443?6, P＜005) and the DL method was applied to evaluate the combined value. RR(relative risk) was 05565 and its 95％CI(95％ Confidence Interval) was 0544?6 to 0568?7, and PR(protective rate) was 4435％. ② Results of the two studies in the southern areas were homogenous (Q=0068?4,P＞005). RR(95％CI)was 0673?5(0576?7 to 0786?5) and PRwas 3265％. Results of the ten studies in the northern areas were homogenous (Q=16553?8, P＞005). RR(95％CI)was 0513?1(0428?3 to 0614?6)and PR　was 4869％. ConclusionRisks of NTDs were reduced after putting integrated intervention measurements on women of childbearing age, but the whole protective rate did not reach the expectation. The protective rate in the northern areas was better than that in the southern areas. Integrated intervention measurements should be improved in order to make them work more effectively.

Key words: Neural tube defects, Intervention measures, Metaanalysis, Women