Abstract:

Objective To explore the value of urine AD7c-NTP assay in clinical diagnosis of Alzheimer's disease (AD). Methods  The urine AD7c-NTP level was determined using Enzyme-linked immunosorbent assay in 245 elderly people, who were divided into three groups: the  AD group(n=65)，the  vascular dementia group (VaD, n=60) and the normal mental state group (n=120). Statistical analysis was performed using SPSS 13.0. Results  The urine AD7cNTP content of the three groups were (2.50±0.45)ng/ml, (1.19±0.68)ng/ml and (1.21±0.74)ng/ml. Compared with the normal mental state group and the VaD group, AD group had a significant increase of the urine AD7c-NTP level, which was positively correlated with the severity of the disease. No significant difference was found between the VaD group and the normal mental state group. Conclusion  Urine AD7c-NTP level, probably a biochemical marker of AD, is of important and practical value in clinical diagnosis and condition assessment of AD.

Key words: Alzheimer disease; Dementia, vascular; AD7c-NTP; Enzymelinked immunosorbent assay; Urine