关键词: 易感基因, HLA抗原, 基因频率, 尿毒症, 慢性肾小球肾炎

Abstract:

Objective〓〖WTBZ〗To explore the association between chronic glomerulonephritis(CGN) and the human leukocyte antigen(HLA)-DRB1 on DNA levels and to find susceptibility genes and protective genes, so as to further explain the possible pathogenesis of CGN. 〖WTHZ〗Methods〓〖WTBZ〗1?073 Han renal transplantation patients were included in this study. All patients were recruited from three provincial Hospitals during the past ten years. The control group contained 7418 healthy Han volunteer donors from the Shandong Hematopoietic Stem Cell Data Bank of China. We collected data about the polymorphism of HLA-DRB1. Gene frequency (GF), relative risk (RR)and correlation test were analyzed by using statistical software. Some patients carrying the susceptibility genes were followed up 1, 3 and 5 years, and their survival rates were compared. 〖WTHZ〗Results〓〖WTBZ〗The frequency of the HLA-DRB1*18 allele increased more significantly in the CGN patients than in controls. They might be the suspicious susceptibility genes of CGN. After the follow-up, the prognosis of patients with the susceptibility genes was worse than that of the controls. However, the frequency of the HLA-DRB1*16 alleles decreased more significantly in the CGN patients than that in the controls. They might be the protective genes of CGN. 〖WTHZ〗Conclusion〓〖WTBZ〗There might be corresponding susceptibility and protective genes of CGN in the Shandong Han population, and interestingly, the prognosis of patients with the susceptibility genes is worse than that of the controls.

Key words: Chronic glomerulonephritis, Uremia, HLA antigens, Gene frequency, Susceptibility genes