气道上皮及其源性细胞因子与哮喘:思考与展望

doi:10.6040/j.issn.1671-7554.0.2024.0121

摘要/Abstract

摘要： 气道上皮通过与免疫细胞的紧密互作精细调控并维持气道微环境的形成,在哮喘免疫病理进展过程中处于核心地位。气道上皮源性细胞因子被认为在触发和维持哮喘气道炎症中担任关键角色,成为目前哮喘新型药物研发的热门靶点。本文综述气道上皮及其源性细胞因子在哮喘中的作用及相关靶向药物研究进展,为相关研究提供新视角与新思考。

关键词: 气道上皮, 细胞因子, 哮喘, 靶向药物, 展望

Abstract: The airway epithelium plays a central role in the pathogenesis of asthma by tightly interacting with immune cells and finely regulating the formation of the airway microenvironment. Epithelial-derived cytokines have been recognized as key players in triggering and sustaining airway inflammation in asthma, making them attractive targets for the development of novel asthma drugs. This article provides an overview of the role of the airway epithelium and its derived cytokines in asthma, as well as the progress in research on targeted drugs, offering new perspectives and insights for related studies.

Key words: Airway epithelium, Cytokines, Asthma, Targeted medicine, Outlook

中图分类号:

R562

张锦涛,董亮. 气道上皮及其源性细胞因子与哮喘:思考与展望[J]. 山东大学学报 (医学版), 2024, 62(5): 1-6.

ZHANG Jintao, DONG Liang. Airway epithelium and epithelial-derived cytokines in asthma: reflection and outlook[J]. Journal of Shandong University (Health Sciences), 2024, 62(5): 1-6.

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