肺动脉灌注HTK液对肺动脉高压先心病患儿术后的肺保护作用

山东大学学报(医学版) ›› 2010, Vol. 48 ›› Issue (6): 88-91.

肺动脉灌注HTK液对肺动脉高压先心病患儿术后的肺保护作用

李金东，王安彪，张海洲，许崇恩，李德才，范全心，邹承伟

山东大学附属省立医院心脏外科，　济南 250021

收稿日期:2010-01-03 出版日期:2010-06-16 发布日期:2010-06-16
通讯作者: 王安彪（1966- ）男，主任医师，研究方向为先心病的诊治及先心病的肺保护。 E-mail:abwang0607@sina.com
作者简介:李金东（1983- ）男，硕士研究生，研究方向为先心病的诊治及肺保护

Effect of pulmonary artery perfusion with HTK solution to congenital heart disease patients with pulmonary hypertension

LI Jindong, WANG Anbiao, ZHANG Haizhou, XU Chongen, LI Decai, FAN Quanxin, ZOU Chengwei

Department of Cardiac Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China

Received:2010-01-03 Online:2010-06-16 Published:2010-06-16

摘要/Abstract

摘要：

目的研究体外循环期间肺动脉灌注HTK保护液对合并肺动脉高压的先心病患儿的肺保护作用。方法将40例合并肺动脉高压的先心病患儿随机分为灌注组（体外循环+HTK液肺动脉灌注，n＝20）和对照组（体外循环, n＝20），进行心内畸形矫治，并于麻醉前、主动脉开放时、开放后6 、12 、24h 分别抽取动脉血样，测定血清中白介素-6（IL-6）和丙二醛（MDA）的浓度，并在相应的时间点抽取动脉血样行血气分析，计算各时间点的呼吸指数（RI）及氧和指数（OI）。结果术后两组患儿血清中IL-6和MDA的浓度较术前明显升高，但灌注组明显低于对照组（P＜0.05）。灌注组患儿术后的RI及OI明显好于对照组（P＜0.05）。结论体外循环期间行肺动脉灌注HTK液对合并肺动脉高压的先心病患儿有一定的肺保护作用。

关键词: 体外循环；肺动脉灌注；HTK液；肺保护

Abstract:

Objective To determine the effect of pulmonary perfusion with HTK solution on lung function during cardiopulmonary bypass (CPB) . Methods Fourty congenital heart disease patients with pulmonary hypertension were randomly divided into two groups. During CPB, the study group were perfused with 4℃ HTK solution while the control group were not. IL-6, MDA,RI and OI were measured at different time points. Results The plasma levels of IL-6 and MDA in the study group were lower than those in the control group, and the difference was significant (P＜0.05）. At each measuring point, OI of the study group was significantly higher than that of the control group (P<0.05). RI of the study group was significantly lower than that of the control group (P<0.05) after CPB. Conclusion This study demonstrated that pulmonary artery perfusion with HTK solution can obviously reduce lung injury after cardiopulmonary bypass.

Key words: Cardiopulmonary bypass； Pulmonary artery perfusion； HTK solution； Lung protection

中图分类号:

R 654.1

李金东，王安彪，张海洲，许崇恩，李德才，范全心，邹承伟. 肺动脉灌注HTK液对肺动脉高压先心病患儿术后的肺保护作用[J]. 山东大学学报(医学版), 2010, 48(6): 88-91.

LI Jindong, WANG Anbiao, ZHANG Haizhou, XU Chongen, LI Decai, FAN Quanxin, ZOU Chengwei. Effect of pulmonary artery perfusion with HTK solution to congenital heart disease patients with pulmonary hypertension[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(6): 88-91.

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