化疗对食管癌患者外周血CD4+CD25+调节性T细胞的影响

山东大学学报(医学版) ›› 2010, Vol. 48 ›› Issue (6): 104-.

化疗对食管癌患者外周血CD4+CD25+调节性T细胞的影响

刘光英1,李小娜1，张娜1，王功朝1,2

山东大学 1.护理学院临床教研室，济南 250012; 2.附属省立医院胸外科，济南 250021

收稿日期:2010-01-19 出版日期:2010-06-16 发布日期:2010-06-16
通讯作者: 王功朝（1966- ），博士，副教授，主要从事肿瘤免疫、胸部肿瘤的外科治疗方面的研究。 E-mail:gongchao@sdu.edu.cn
作者简介:刘光英（1986- ），硕士研究生，主要从事心血管护理、急危重症护理的研究。

The impact of chemotherapy on CD4+CD25+ regulatory T cells in peripheral blood of the postoperative patients with esophageal cancer

LIU Guangying1 , LI Xiaona1, ZHANG Na1, WANG Gongchao1，2

1. Clinical Teaching and Research Section of School of Nursing, Shandong University, Jinan 250012, China；
2. Department of Chest Surgery, Provincial Hospital Affiliated to Shandong University， Jinan 250021， China

Received:2010-01-19 Online:2010-06-16 Published:2010-06-16

摘要/Abstract

摘要：

目的探讨化疗对食管癌术后患者外周血CD4+CD25+调节性T细胞的影响。方法随机选择35例食管癌术后化疗患者，应用流式细胞仪检测其化疗前、化疗1周后外周血CD4+CD25+调节性T细胞的比例，并进行比较，选择30例健康志愿者作为对照。结果食管癌患者术后化疗前外周血中CD4+CD25+调节性T细胞的比例(10.44±1.45)%高于同期健康对照组（9.35±1.41）%，差异有统计学意义（t=3.059,P＜0.05）。35例患者其化疗前及化疗1周后外周血CD4+CD25+调节性T细胞比例分别为：(10.44±1.45)%、(11.67±1.56)%，两者比较差异具有统计学意义（t=6.342,P＜0.01）。结论化疗可增高食管癌术后患者外周血CD4+CD25+调节性T细胞的比例。

关键词: 化疗；食管肿瘤；CD4+CD25+调节性T细胞

Abstract:

Objective To investigate the impact of chemotherapy on CD4+CD25+ regulatory T cells in peripheral blood of the postoperative patients with esophageal cancer. Methods 35 postoperative esophageal cancer patients undergoing chemotherapy were randomly selected. Proportions of CD4+CD25+ regulatory T cells in peripheral blood of the patients were detected using FACSCalibur (FACScan) before and 1 week after chemotherapy, and were compared with those of 30 healthy volunteers who were randomly selected as the control group. Results Proportions of CD4+CD25+ regulatory T cells in peripheral blood of the 30 healthy volunteers and 35 patients before and 1 week after chemotherapy were （9.35±1.41）% vs (10.44±1.45)% and (10.44±1.45)% vs (11.67±1.56)% respectively，and there were significant differences between them（t=3.059,P＜0.05 and t=6.342,P＜0.01）. Conclusion Chemotherapy could increase the proportion of CD4+CD25+ regulatory T cells in peripheral blood of the postoperative patients with esophageal cancer.

Key words: Chemotherapy; Esophageal tumor; CD4+CD25+ regulatory T cell

中图分类号:

R329.11

刘光英1,李小娜1，张娜1，王功朝1,2. 化疗对食管癌患者外周血CD4+CD25+调节性T细胞的影响[J]. 山东大学学报(医学版), 2010, 48(6): 104-.

LIU Guangying1 , LI Xiaona1, ZHANG Na1, WANG Gongchao1，2 . The impact of chemotherapy on CD4+CD25+ regulatory T cells in peripheral blood of the postoperative patients with esophageal cancer[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(6): 104-.

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