细胞因子诱导的杀伤细胞治疗妇科恶性肿瘤的近期疗效观察

山东大学学报(医学版) ›› 2010, Vol. 48 ›› Issue (11): 121-.

细胞因子诱导的杀伤细胞治疗妇科恶性肿瘤的近期疗效观察

张蓓1, 2，闫莉2，周婷2，荣风年2

山东大学 1.医学院，济南 250012； 2.附属千佛山医院妇产科, 济南 250014

收稿日期:2010-09-11 出版日期:2010-11-16 发布日期:2010-11-16
通讯作者: 荣风年(1960- ),女,主任医师，主要从事妇科肿瘤的研究。 E-mail：fn. rong@ yahoo. com. cn
作者简介:张蓓(1984- ),女,硕士研究生,主要从事妇科肿瘤的研究。

Short-term curative efficacy of cytokine-induced killer cells on patients with gynecological malignant carcinoma

ZHANG Bei1,2, YAN Li2, ZHOU Ting2, RONG Feng-nian2

1. School of Medicine, Shandong University, Jinan 250012, China;
2.Departmen of Gynecology and Obstetrics, Qianfoshan Hospital Affiliated to Shandong University, Jinan 250014, China

Received:2010-09-11 Online:2010-11-16 Published:2010-11-16

摘要/Abstract

摘要：

目的观察回输体外培养的自体细胞因子诱导的杀伤细胞（cytokine-induced killer cells, CIK）治疗妇科恶性肿瘤的近期临床疗效。方法取8例妇科恶性肿瘤患者外周血，体外培养诱导出CIK细胞，将CIK细胞回输给患者，对比其回输前及回输后2个月的免疫功能、血清CA-125值、卡氏评分及临床症状变化，评价其近期临床疗效。结果回输后，外周血CD4+/CD8+比值增加(P<0.05)， CD3-CD16+CD56+ 细胞所占百分比增加(P<0.05)， CD4+CD25+细胞所占百分比降低(P<0.05)；5例患者血清CA-125值下降；1例患者卡氏评分上升；5例患者自觉有临床症状缓解；无一例出现回输不良反应。结论回输自体CIK细胞对治疗妇科恶性肿瘤有一定的近期疗效。

关键词: 细胞因子诱导的杀伤细胞；妇科恶性肿瘤；免疫治疗

Abstract:

Objective To observe the short-term curative efficacy of transfusing autogeneic cytokine-killer cells(CIK) cultured in vitro on patients with gynecological malignant carcinoma. Methods Blood samples isolated from 8 patients with gynecological malignant carcinoma were induced in vitro to obtain CIK, which were then transfused into the patients. The short-term curative efficacy was evaluated by comparison of the immunological function, level of CA125 in serum, Karnofsky performance score(KPS) and change of clinical symptoms before and two months after transfusion. Results After transfusion, both the ratio of CD4+/CD8+ and percentage of CD3-CD16+CD56+ in peripheral blood were increased(P<0.05),while the percentage of CD4+CD25+ was decreased(P<0.05). The level of CA125 in serum was decreased in 5 cases. The KPS was increased in one case. Clinical symptoms were ameliorated in 5 cases. At the same time, no adverse reaction was observed. Conclusion Transfusing autogeneic CIK has some short-term curative efficacy on gynecological malignant carcinoma.

Key words: Cytokine-induced killers cells; Gynecological malignant carcinoma; Immunotherapy

中图分类号:

R737. 31

张蓓1, 2，闫莉2，周婷2，荣风年2. 细胞因子诱导的杀伤细胞治疗妇科恶性肿瘤的近期疗效观察[J]. 山东大学学报(医学版), 2010, 48(11): 121-.

ZHANG Bei1,2, YAN Li2, ZHOU Ting2, RONG Feng-nian2. Short-term curative efficacy of cytokine-induced killer cells on patients with gynecological malignant carcinoma[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(11): 121-.

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