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山东大学学报(医学版) ›› 2009, Vol. 47 ›› Issue (8): 75-78.

• 论文 • 上一篇    下一篇

辛伐他汀对COPD患者细胞凋亡和炎症因子的干预作用

王永彬,王伟   

  1. 山东大学第二医院呼吸内科, 济南    250033
  • 收稿日期:2009-03-23 发布日期:2009-08-16
  • 作者简介:王永彬(1981- ),男,硕士研究生,主要从事慢性阻塞性肺疾病的研究。 Email:ybinwang@163.com

Effects of Simvastatin on the levels of plasma Fas/Apo1 and inflammatory factors in patients with chronic obstructive pulmonary disease

WANG Yongbin, WANG Wei    

  1. Department of Respiratory Diseases,  Second Hospital of Shandong University, Jinan 250033, China
  • Received:2009-03-23 Published:2009-08-16

摘要:

目的探讨辛伐他汀对慢性阻塞性肺疾病(COPD)稳定期患者的抗炎及调节细胞凋亡的作用及其机制。方法随机将60例COPD稳定期患者分为干预组和对照组,干预组给予辛伐他汀20?mg顿服,治疗8周,于治疗前、后记录临床症状得分并检查肺功能、血浆Fas/Apo1、肿瘤坏死因子α(TNFα)及白介素8(IL8)的含量。健康对照组27例,不予处理,只采血检测。结果COPD稳定期患者血浆Fas/Apo1、TNFα、IL8水平均明显高于健康对照组(P<0.05);治疗后干预组和对照组的FEV1 和FEV1占预计值(%)较本组治疗前无明显差异(P>0.05),临床症状得分、Fas/Apo1、TNFα、IL8水平两组相比明显降低(P<0.05);干预组的临床症状得分、Fas/Apo1、TNFα、IL8水平均较本组治疗前明显降低(P<0.05),而COPD对照组治疗前、后差异不显著。结论辛伐他汀对COPD稳定期患者有抗炎和调节细胞凋亡作用。

关键词: 肺疾病,慢性阻塞性;细胞凋亡;炎症;辛伐他汀

Abstract:

To observe the influence of simvastatin on clinical symptoms,pulmonary function and plasma levels of Fas/Apo1, tumor necrosis factorα(TNFα)and interleukin8 (IL8) in patients with chronic obstructive pulmonary disease(COPD) and investigate the therapeutic action of Simvastatin on COPD. MethodsSixty COPD patients during a stable phase were randomly divided into two groups on average and received either simvastatin 20?mg once daily(the intervention group) or a placebo (the control group ) for 8 weeks. In addition, 27 healthy persons were enrolled as the healthy control group.The clinical symptom scores, pulmonary function and the levels of plasm  Fas/Apo1,TNFαand IL8 were measured before and after treatmentResults There  was no  significant differences in FEV1 and FEV1 % between the intervention group and the control group before and after treatment (all P>0.05). The levels of plasm  Fas/Apo1, TNFα and IL8 were significantly higher in the intervention group than in healthy control group(P<0.05). The clinical symptom scores and the levels of plasm  Fas/Apo1,TNFα and IL8 were significantly decreased after treatment in the intervention group(P<0.05). There were significant differences in the clinical symptom scores and the levels of plasm Fas/Apo1,TNFα and IL8 between the intervention group and the control group after treatment(P<0.05). ConclusionSimvastatin can reduce circulating markers of inflammation and accommodate cell apoptosis in COPD patients during a stable phase.

Key words: Pulmonary disease, chronic obstructive; Apoptosis; Inflammation; Simvastatin

中图分类号: 

  • R563
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