JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Effect of the Shenqi Jiedu decoction on chronic renal failure: an experimental study

LI Yun, SI Guo-min， ZHANG Yun   

  1. Department of Traditional Chinese Medicine, Shandong Provincal Hospital, Shandong University, Jinan 250021, Shandong, China
  • Received:2007-03-05 Revised:1900-01-01 Online:2007-10-24 Published:2007-10-24
  • Contact: SI Guo-min

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Abstract: Objective： To investigate the effects of the Shenqi Jiedu decoction on chronic renal failure(CRF). Methods: Rat models of CRF were established by feeding Adenine. All the rats were randomly divided into five groups: the normal group, the model group, the high dose Shenqi Jiedu decoction group, the low dose Shenqi Jiedu decoction group and the losartan group. After 8 weeks, levels of serum creatinine (SCr), blood urea nitrogen(BUN), plasma albumin(ALB), triglyceride(TG), cholesterol(CHO), Leptin were determined. In addition, the results of pathology were found and the expression of TGF-β1 was determined. Results： Compared with the model group, levels of SCr and BUN in the Shenqi Jiedu decoction groups and the losartan group were decreased while level of ALB was increased (P＜0.05). Pathological results of the Shenqi Jiedu decoction groups and the losartan group were better than those of the model group, and those of the high dose Shenqi Jiedu decoction group were the best. Compared with the model group, expression of TGF-β1 in the Shenqi Jiedu decoction groups and the losartan group were decreased. Conclusions: Shenqi Jiedu decoction can efficiently decrease the SCr, BUN, and Leptin levels and increase the ALB level, reduces the pathological injury and the TGF-β1 expression, and postpones the aggravation of the renal function.

Key words: Chronic renal failure, Shenqi Jiedu decoction, transforming growth factor, Leptin, Rats, Wistar

CLC Number: 

  • R692.5
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