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Durability of the effects after cessation of lamivudine for 47 patients with HBeAg-negative chronic hepatitis B

LI Xiao-ying, WANG Lei, LIU Feng   

  1. Jinan Infectious Disease Hospital, School of Medicine, Shandong University,Jinan 250021, Shandong, China
  • Received:2006-12-10 Revised:1900-01-01 Online:2007-09-24 Published:2007-09-24
  • Contact: WANG Lei

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Abstract: Objective: To investigate the durability of the effects after cessation of lamivudine for HBeAg-negative chronic hepatitis B(CHB) patients. Methods: Forty-seven patients subjecting to lamivudine for no less than 24 months and their HBVDNA-negative duration more than 18 months were enrolled in this study. Hepatic biochemical parameters, HBV-DNA determination, and follow-up were determined after cessation of lamivudine. Results: The cumulative rate of relapse after 3, 6, 12, 24 and 36 months after cessation of lamivudine was 25.5%, 25.5%, 41.8%, 48.3% and 54.8%, respectively. Twenty-three patients relapsed and the latest happened on the 39th month. The cumulative relapse ratio at month 4, 9 and 12 was 52.2%. 65.2% and 82.6%, respectively. The durability of the effects after cessation of lamivudine was related to age at the end of treatment. Conclusion: Durability of the effects after cessation of lamivudine of HBeAg-negative patients is lower than that of HBeAg-positive ones. The younger the patient is, the lower the relapse rate.

Key words: Chronic hepatitis B, Lamivudine, Durability, Effectiveness

CLC Number: 

  • R575.1
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