JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Effects of rh-GH on experimental remodeling of powered periodontal tissues of rats

HUANG Yan1，WANG Xu-xia1，ZHANG Wen-juan2，LIU Chao1，ZHANG Jun1   

  1. 1.Department of Orthodontics, School of Stomatology, Shandong University；2.Department of Stomatology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine
  • Received:2007-03-09 Revised:1900-01-01 Online:2007-09-24 Published:2007-09-24
  • Contact: ZHANG Jun

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Abstract: Objective: To investigate the effect of rh-GH on experimental remodeling of powered periodontal tissues during orthodontic tooth movement in adult rats. Methods: Thirty female 7 week old SPF Wister rats were randomly divided into three groups: the control group, the NS group, the rh-GH group. The orthodontic tooth movement models were established by operation. The distance of tooth movement was measured and the periodontal tissues were histologically studied. Results: The distance of tooth movement of the control group was the shortest, that of the NS group was the longest, and that of the rhGH groual was shorter than that of the NS group and longer than that of the control group in the three groups. All the results had statistical significances. rh-GH significantly improved the periodontal membrane condition and may promote alveolar bone forming and inhibit bone resorption. Conclusion: rh-GH may slow the tooth movement of adult rats and improve the remodeling of powered periodontal tissues.

Key words: rh-GH, Adult orthodontics, Periodontal tissue, Remodeling

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