Abstract: Objective: To investing the possibility of esophageal remodeling in situ induced by resorbable porcinederived, xenogeneic aortas acelullar tissue matrix (ACTM) for cervical esophageal defect repair in a dog model. Methods: Xenogeneic ACTM was made by trypsin and Triton X100. Esophageal segmental defect measuring 5 cm in length was created by surgical resection in 6 mature Chinese mongrel health dogs, then the defect was repaired with ACTM. The animals were kept alive for periods. The surviving and healing process were observed. Results: Porcine ACTM could be obtained successfully by trypsin and Triton X100. There were no deaths after perioperative period. One dog had anastomotic leakage, 1 died of esophagus rupture when esophageal dilation was performed. Submucosal tissue regeneration and abundant neovascularization were found at postoperative 14 days. Bundles of muscle cells were found, and the squamous epithelia covered the entire grafts surface 28 days after surgery. The graft material itself could not be identified in gross inspection after 12 weeks. Conclusion: ACTM is promising as an ideal treatment option for esophageal repair， it can be resorbed and remodeled esophagus well. These result shows that esophageal remodeling in situ induced by porcine ACTM will be feasible in the near future for esophageal reconstruction.

Key words: Artificial esophagus, Aortas acellular tissue matrix, Esophagus reconstruction, Animal, laboratory, Dogs