Abstract: Objective： To study the quantitative morphometric changes of the corneal endothelial cells in acute angle-closure glaucoma and its related factors． Methods: A total of 27 patients (54 eyes) with acute angle-closure glaucoma were divided into two groups based on the pathogenetic condition: the control group (eyes in pre-clinical stage, n=27) and the experimental group (eyes in the acute attack stage, n=27). The experimental group was subdivided into two groups based on the intraocular pressure: the A1 group (＜60mmHg) and the B1 group (≥60mmHg), and another two groups based on the course of the disease: the A2 group (＜7days) and the B2 group (≥7days). Cell density, percentage of hexagonal cells, and average cellular area of the corneal endothelium were determined by a non-contact specular microscope and a computer-aid image analysis system. The statistical significance of the above indexes was determined between the two groups. Results: Compared with the control group， cell density and percentage of hexagonal cells (P＜0.01) were significantly decreased in the experimental group but the average cellular area was significantly increased (P＜0.01). There were significant group and the B2 group (P＜0.05). Conclusions: Cell density is significantly decreased but cell pantomorphia is increased in eyes of the acute attack stage. The quantitative morphometric changes of the corneal endothelial cells significantly relate to the intraocular pressure with the course of the disease.

Key words: Glaucoma, angle-closure, Acute disease, Endothelium, Corneal, Cells