JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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High expression of α-SMA and type Ⅰ collagen induced by transcription factor T-bet/GATA-3 ratio in asthma models

TIAN Hong, WANG Shu-juan, LI Hong-jia, DONG Liang   

  1. Department of Pulmonary Disease, Qilu Hospital of Shandong University, Jinan 250012, China
  • Received:2007-04-17 Revised:1900-01-01 Online:2007-11-24 Published:2007-11-24
  • Contact: DONG Liang

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Abstract: ObjectiveTo study the relationship between transcription factor T-bet/GATA -3 and expression of α-smooth muscle actin (α-SMA) and type Ⅰ collagen in asthma. MethodsThe levels of T-bet and GATA-3 in rat lungs were determined by quantitative real-time PCR and western blotting respectively. α-SMA and type Ⅰ collagen levels in lung fibroblasts were determined by immunohistochemistry and ELISA respectively. ResultsThe expression of T-bet mRNA and protein in the OVA group was significantly attenuated compared with that in the saline group and the blank group, while the expression of GATA-3 in the OVA group was significantly increased and the T-bet/GATA-3 ratio in the OVA group was significantly decreased. The α-SMA and type Ⅰ collagen levels in the OVA group were significantly increased. The T-bet/GATA-3 ratio had a negative correlation with α-SMA and type Ⅰ collagen. There was no significant difference between the saline group and the blank group. ConclusionThe T-bet/GATA3 ratio has a negative relation to α-SMA and type Ⅰ collagen, and T-bet/GATA3 imbalance plays a crucial role in asthma models.

Key words: Asthma, T box expressed in T cells/GATA binding protein-3, α-smooth actin, Type Ⅰ collagen

CLC Number: 

  • R562.25
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