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D2-40 positive micro-lymphatic vessel density in the thyroid papillary carcinoma correlate with lymphatic metastasis

LIU Hong， ZHANG Jian-ping， ZHAO Zhu-mei， WANG Yan， LIU Wen-jun， ZHANG Ze-li， LI Hong   

  1. Department of Pathology， School of Medicine， Shandong University， Jinan 250012， Shandong， China
  • Received:2006-11-10 Revised:1900-01-01 Online:2007-03-24 Published:2007-03-24
  • Contact: ZHANG Jian-ping

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Abstract: Objective: Specimens of papillary thyroid carcinoma and nodular goiter have been immunohistochemically studied by using a novel monoclonal antibody D2-40 which is specific against lymph epithelial cells in the detection of the newly formed micro-lymphatic vessel density（MLVD） in lesions in order to seek clues of papillary thyroid carcinoma and its well known ability to involve regional lymph nodes. Micro-vascular density（MVD）as the future of tumor angiogenesis was immunochemically compared by CD34. Methods: MLVD and MVD were determined by conventional HE staining and Envison immunohistochemistry using D2-40 and CD34 monoclonal antibodies in 46 specimens of papillary thyroid carcinoma and 20 of nodular goiter. Results: The micro-lymphatic vessel of papillary thyroid carcinoma in the peripheral zone of stroma appeared to be associated with the spread of tumors to regional lymph nodes. Conclusion: The metastasis process of thyroid papillary carcinoma is associated with the formation of the micro-lymphatic vessel and micrangium. The antimetastatic potential for targeting these lymphatics may be of potential therapeutic benefit in the future.

Key words: Thyroid neoplasms, Antigens, Lymphnode metastasis, Immunohistochemistry

CLC Number: 

  • R736.1
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