JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• Articles • Previous Articles     Next Articles

Expression and signficance of TNF-related apoptosis inducing ligand and death receptor-5 in atherosclerosis rabbits

FEI Ling1，SUI Shu-jian1，REN Man-yi1，XU Fu-yu2，LIU Wei-hua1，DU Yi-meng1   

  1. 1. Department of Cardiology； 2. Department of Pathology， Second Hospital of Shandong University, Jinan 250033, Shandong, China
  • Received:2006-06-30 Revised:1900-01-01 Online:2007-02-24 Published:2007-02-24
  • Contact: SUI Shu-jian

PDF (PC)

1415

Abstract: Objective: To explore whether TNF-related apoptosis inducing ligand（TRAIL）and death receptor-5(DR5) take part in the occurrence and development of atherosclerosis（AS）. Methods: Twenty rabbits were randomly distributed into two groups: the control group and the atherosclerotic group. The experimental atherosclerotic models were made by endothelial injury on the ventro-aorta with a balloon and hyperlipid feeding lasting 12 weeks. The levels of sTRAIL and sDR5 in the serum were determined by enzyme linked immunoabsorbent assay (ELISA). The proteinum expression of TRAIL and DR5 in the ventro-aortas was detected by immunohistochemical technique. Results: In the course of research, 2 rabbits died. The survival rate was 90%. Till the end of the research, the serum sDR5 in the AS group was more significantly elevated than that in control group (P＜0.05), while the serum sTRAIL in two groups had no significant differences (P＞0.05). The expressions of TRAIL and DR5 in the ventro-aortas in the AS group were significantly elevated than those in the control group (P＜0.05). Conclusion: This study suggests that TRAIL and DR5 could promote the occurrence and development of AS. TRAIL and DR5 may be important factors for AS.

Key words: Atherosclerosis, Tumor necrosis factor-related apoptosis inducing ligand, Death receptor-5, Apoptosis

CLC Number: 

  • R541
[1] LU Xiang-Dong, YANG Wei, XU Guang-Meng, QU Yuan-Ming. Expression and role of PPAR-γin meningiomas and troglitazone induced meningiomas cell apoptosis in vitro [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 65-.
[2] CHEN Yang, FENG Ying, LU Xiao, ZHENG Rong. Galectin-3 promotes autophagy and polarization of macrophages via the PI3K/Akt/mTOR pathway [J]. Journal of Shandong University (Health Sciences), 2026, 64(4): 14-22.
[3] DUAN Yingzhu, DONG Bo, YU Rui. Mendelian randomization study on the association of intrinsic emotions with coronary atherosclerosis risk in patients with rheumatoid arthritis [J]. Journal of Shandong University (Health Sciences), 2026, 64(4): 63-71.
[4] YIN Yue, MO Zhenfei, WU Peixin, LIU Jinxia, WEI Yuanhui, REN Jiabo, LI Chunsun. Expression of GPX1 in lung cancer cell lines and its influence on the proliferation, migration, invasion abilities and apoptosis in lung adenocarcinoma cell lines [J]. Journal of Shandong University (Health Sciences), 2026, 64(1): 65-73.
[5] LI Xiping, QIU Mei, HUANG Ruifeng, LIN Huihui, LIU Sisi, LUO Hongying, WANG Yuyue, WANG Min, YANG Xiaotong. Research progress on the mechanism of berberines anti-atherosclerosis effects based on the synergistic effect of lipid deposition inhibition and metabolic clearance [J]. Journal of Shandong University (Health Sciences), 2025, 63(9): 77-83.
[6] DU Aijia, ZHANG Man, CHEN He, WANG Lixin, SHANG Yingshu. miR-1270-targeted regulation of angiopoietin-like protein 7 inhibits macrophage inflammation and lipid accumulation [J]. Journal of Shandong University (Health Sciences), 2025, 63(2): 1-9.
[7] LI Xiang, ZHANG Yi, WANG Xuechun, XU Mengchao, WANG Yuelan. Research progress on oxidative stress in acute lung injury induced by traumatic brain injury [J]. Journal of Shandong University (Health Sciences), 2025, 63(2): 118-124.
[8] ZHANG Jie, ZHANG Fangfang, WANG Jingnan, LI Zeyu, SONG Ying, LI Na. Expression of circ_0000144 in breast cancer and its effect on the proliferation, migration and invasion ability of breast cancer cells [J]. Journal of Shandong University (Health Sciences), 2025, 63(1): 35-42.
[9] DU Xueshi, NI Xiangmin, LIANG Xinyu, BAI Qian, ZHU Wenyi, WANG Jian. The protect effect of equol and its potential targets in the context of diabetic nephropathy [J]. Journal of Shandong University (Health Sciences), 2024, 62(8): 49-58.
[10] JIANG Zihan, LU Xingchen, SUN Lu, ZHAO Huichen, ZUO Dan, MA Xiaoli, LIU Yuantao, ZHANG Yuchao. Mechanism of NR4A1 regulating hydrogen peroxide-induced apoptosis in human umbilical vein endothelial cells via the IκBα/NF-κB pathway [J]. Journal of Shandong University (Health Sciences), 2024, 62(3): 11-19.
[11] CAO Hualin, JIA Yanzhao, QU Li, YIN Xin. Impacts of CircFAT1 on the proliferation, apoptosis and radiosensitivity of nasopharyngeal carcinoma cells by regulating miR-296-3p/MAPRE1 axis [J]. Journal of Shandong University (Health Sciences), 2023, 61(9): 38-46.
[12] GAO Yujie, LONG Qifu, HU Ying, XU Yuzhen, WANG Ru, YONG Sheng. Bioinformatics identification of the Hub genes and mechanism of hypoxia-induced mitochondrial damage in mouse kidney [J]. Journal of Shandong University (Health Sciences), 2023, 61(9): 57-68.
[13] LIU Jinbo, LIU Kaiwen, XIANG Chongxin, CHENG Lei. Protective effects of crocin on intervertebral disc degeneration [J]. Journal of Shandong University (Health Sciences), 2023, 61(9): 84-93.
[14] ZHANG Jiaying, SU Rongyun, WANG Yinghui, WANG Honggang, LIU Gang. ACE2 gene protects against renal ischemia-reperfusion injury by regulating the Nrf2/HO-1 signaling pathway [J]. Journal of Shandong University (Health Sciences), 2023, 61(4): 1-9.
[15] XU Tianqi, CHANG Na, ZHANG Shuai, LI Sha, JIAO Bingxuan, YU Xinxin, WANG Ximing. Identification of carotid high-risk plaques by non-alcoholic fatty liver disease based on CTA [J]. Journal of Shandong University (Health Sciences), 2023, 61(12): 36-43.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd