JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• Articles • Previous Articles     Next Articles

Heterozygosity loss at FHIT, SLIT2 and EDNRB gene in endometrical carcinoma

XIE Min1，WEI De-e1，WANG Bo2，LU Ai-ying1   

  1. 1.Department of Gynecology and Obsterics, Jinan Central Hospital, Jinan 250013; 2.Department of Gynecology and Obsterics, Qilu Hospital of Shandong University, Jinan 250012
  • Received:2006-09-29 Revised:1900-01-01 Online:2007-01-24 Published:2007-01-24
  • Contact: XIE　Min

PDF (PC)

702

Abstract: Objective：To study the loss of heterozygosity(LOH) at FHIT, SLIT2 and EDNRB gene at microsatellite markers D3S1287, D4S1593, and D13S160 in endometrial carcinoma. Methods： Tumor tissues and relatively normal tissues of thirty-five cases of endometrial carcinoma were examined by using PCR-denaturing PAGE-silver staining at microsatellite markers D3S1287, D4S1593, and D13S160. Results： The total LOH rate was 54.3%, and LOH rate of D3S1287, D4S1593, and D13S160 was 34.5%, 20.5%, and 19.3%, respectively. The LOH rate at FHIT, SLIT2, and EDNRB gene did not positively correlate with the stage of clinical-pathogensis in endometrial carcinoma. Conclusion： LOH exists at micro-satellite markers of FHIT, SLIT2, and EDNRB gene in endometrial carcinoma, suggesting that FHIT, SLIT2, and EDNRB gene are tumor suppressor genes(TSGs) and the inactivity of TSGs maybe one of the reasons for carcinoma.

Key words: Endometrial neoplasms, Gene, FHIT, Gene, SLIT2, Gene, EDNRB, Loss of heterozygosity

CLC Number: 

  • R737.33
[1] YU De-Xin, CAEI Ti-Gong, MA Xiang-Xing, ZHANG Xiao-Ming, LI Chuan-Fu. Angiogenesis and maturation of hepatocellular carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 51-54.
[2] ZHANG Shi-Bao, LIU Qing-Yong, RUAN Xi-Yun, CHEN Jie, ZHANG Jian-Jun, LI Zong-Wu, YANG Guang-Xiao, WANG Quan-Ying. onstruction and identification of the expression vector of
NT4-SAC-HA2-TAT fusion gene [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 15-19.
[3] ZHANG Xiao-Yan, LI Gang, WANG Ling-Beng. Effects of different dosages of Sufentanil in induced general anesthesia  period on blood rheology cortisol in spinal operations [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 76-79.
[4] GE Li-Juan, JIN Rui-Feng, WANG Ji-Wen, HU Xin-Sheng, LIKun. Association between the C1236T polymorphism in multi-drug resistance gene 1 and response to antiepileptic drug treatment in epileptic patients [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 99-102.
[5] DONG Ping, SHEN Haitao, QIAO Yaqin, LU Yan. Role of autophagy in the regulation of APAP liver injury and liver regeneration process [J]. Journal of Shandong University (Health Sciences), 2026, 64(5): 42-49.
[6] CHEN Yumeng, ZHANG Yue, ZHANG Wulin, YANG Guoxing, XU Yanhui, HAN Aijun, LIU Caijuan, GUO Yuyu, CHEN Zhimin. Evaluating the efficacy of large language models in answering questions from parents of children with congenital lens dislocation [J]. Journal of Shandong University (Health Sciences), 2026, 64(5): 88-95.
[7] DUAN Yingzhu, DONG Bo, YU Rui. Mendelian randomization study on the association of intrinsic emotions with coronary atherosclerosis risk in patients with rheumatoid arthritis [J]. Journal of Shandong University (Health Sciences), 2026, 64(4): 63-71.
[8] ZHAO Wanxia, ZHAN Qunzhang, JIN Ting, LIU Yuxin, QU Chongzheng, WU Jianchun. Mendelian randomization analysis of the causal relationships between gut microbiota, blood metabolites, and obesity [J]. Journal of Shandong University (Health Sciences), 2026, 64(4): 72-82.
[9] Intelligent Orthopedics Subgroup of Chinese Association of Orthopedic, Subgroup for Prevention and Control of Spinal and Spinal Cord Injury Diseases of Professional Committee for Prevention and Control of Spinal Diseases of Chinese Preventive Medicine Association. Expert consensus on measurement sites and annotation of artificial intelligence-based spinal degenerative imaging(2025) [J]. Journal of Shandong University (Health Sciences), 2026, 64(2): 1-10.
[10] YU Haozhi, SHI Guidong, XU Guopeng, JIANG Yunpeng, FENG Shiqing, LIU Xinyu, QI Lei. Research progress of antioxidant carbon dot nanozymes to regulate the neuro-regeneration microenvironment [J]. Journal of Shandong University (Health Sciences), 2026, 64(2): 44-49.
[11] QI Shuo, LIU Keyu, XU Zhanwang, TAN Guoqing, ZHANG Qiang. Improved biopsy and optimized metagenomic next-generation sequencing strategies for early diagnosis of lumbar disc infection [J]. Journal of Shandong University (Health Sciences), 2026, 64(2): 96-103.
[12] ZHANG Qiuping, ZHU Huizhi, LYU Chuan, XIA Yongqi, ZHANG Xiu. Identification of potential key autophagy- and ferroptosis-related genes in asthma based on bioinformatics analysis [J]. Journal of Shandong University (Health Sciences), 2026, 64(1): 74-87.
[13] WANG Haozheng, ZHANG Wenxiong. Q fever complicated by infection after thoracoabdominal aortic aneurysm stent implantation: a case report and literature review [J]. Journal of Shandong University (Health Sciences), 2026, 64(1): 126-130.
[14] LI Jing, JU Weihang, LIU Ke. Pan-cancer cell type-specific gene-gene co-expression pattern [J]. Journal of Shandong University (Health Sciences), 2025, 63(9): 31-39.
[15] DING Xiaoman, LYU Yan, SUN Jiawen, ZHAO Baotian, QI Na, JIAO Haitao. Epidemiological and genotyping characteristics of human rhinovirus among influenza-like illness in children in Jinan from March 2019 to February 2024 [J]. Journal of Shandong University (Health Sciences), 2025, 63(7): 102-108.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd