Abstract: Objective： To investigate the role of recombined human BMP-7 in the bone formation of implanted interface microregion. Methods: A histological microscope was used to observe the morphology, the histological chemistry method was used to determine the ALP activity and electronic probe X -ray microregion analysis was used to evaluate the element of the interface. Results: Two weeks after the implantation, an amount of new bone formation was observed through the histological microscope and at 6 weeks it nearly reached the bone integrated. The ALP activity was very high at two weeks after the implantation and almost reached a peak value at 6 weeks, and then it remained steady. The percentage of Ca and P increased rapidly and reached a peak at 6 weeks, and then it remained steady and persisted with the time. Conclusion： Recombination human BMP-7 may promote bone interface formation in oral implants.

Key words: Implant, Electron probe, Microanalysis, Recombinant proteins