JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Expression of Maspin and its significance in human nonsmall cell lung cancer

SUN Ping,PAN Xiang-lin1,QU Gui-mei,WANG Wei   

  1. 1. Department of Oncology,Second Hospital of Shandong University, Jinan 250033, Shandong, China;2. Department of Pathology, Yantai Yuhuangding Hospital, Yantai 264000, Shandong, China
  • Received:2006-03-20 Revised:1900-01-01 Online:2006-10-24 Published:2006-10-24
  • Contact: SUN Ping

Abstract: To study the expression of Maspin in human nonsmall cell lung cancer. Methods: A immunohistochemical method PictureTM was used to detect maspin in 94 cases of lung cancer, 54 of normal bronchial mucosas and 28 of innocent diseases. Results: Maspin expressed itself in 100.00%， 89.28%, 54.26% of normal bronchial epithelial cell,innocent disease, non small cell lung cancer，respectively（P＜0.05). It correlated with LN(+)and TNM staging but did not with histological type and classification degree. Conclusion: Maspin significantly decreases in NSCLC, and it may be a sensitive predictor of metastasis and prognosis for NSCLC.

Key words: Carcinoma, nonsmallcell lung, Gene，maspin, Immunohistochemistry

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