JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Dissolutions and bioavailabilities of temozolomide capsules

WANG Hai-Na1,ZHANG Jun-ren11, PANG Hua2,JI Jian-po3   

  1. 1. Institute of Pharmaceutical analysis, School of Pharmacy, Shandong University, Jinan 250012, Shandong, China;2. Institute of Organic Chemistry, School of Chemistry, Shandong University, Jinan 250012, Shandong, China;
  • Received:2006-03-29 Revised:1900-01-01 Online:2006-09-24 Published:2006-09-24

Abstract: To study three morphological temozolomide (TM) capsules′ dissolutions and absolute bioavailabilities in rabbits. Methods: The dissolution of differently morphological TM capsules was determined by UV spectrophotometry. The pharmacokinetics and bioavailability of three morphologies (A, B and C) in rabbits were studied. Results: The results from Weibull′s analysis showed that the dissolutions of TM capsules were very different, the dissolution rate of TM(C) was the fastest and that of TM(B) was the slowest; The bioavailability of TM(A) and TM(B) were bioequivalent (P＞0.05), but that of TM(C) was obvious lower than the others (P＜0.01). Conclusion: TM capsule A and B are bioequivalent and TM(C) is lower in the bioavailability in rabbits.

Key words: Temozolomide, Polymorphism, Capsule, BioavailabilitY

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