Journal of Shandong University (Health Sciences) ›› 2025, Vol. 63 ›› Issue (2): 77-83.doi: 10.6040/j.issn.1671-7554.0.2024.0285

• Clinical Medicine • Previous Articles     Next Articles

A mendelian randomization study on the association between appendectomy and the risk of colorectal cancer

CHANG Yu1, HU Yunfeng1, WANG Huifeng2, GUO Jing1, ZHANG Tiao1, HAO Yaqin1, LIU Yu1   

  1. 1. Department of Radiotherapy;
    2. Department of Gastroenterology, Yanan University Affiliated Hospital, Yanan 716000, Shaanxi, China
  • Online:2025-03-10 Published:2025-03-07

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Abstract: Objective To explore the causal relationship between appendectomy and colorectal cancer at the genetic level by a two-sample Mendelian randomization(MR). Methods The analysis was conducted using methods such as inverse variance weighting(IVW), MR Egger, weighted median, and both simple and weighted modes. Using summary data from genome-wide association studies(GWAS), the causal relationship between appendectomy and colorectal cancer was assessed. Sensitivity analyses were performed using leave-one-out analysis, Cochrans Q test, MR-Egger regression intercept test, and MR-PRESSO test to evaluate the heterogeneity, pleiotropy, and stability of the instrumental variables. Results The random-effects IVW results indicated that appendectomy hasd no genetic causal relationship with colorectal cancer(OR=1.13, 95%CI:0.29-4.36, P=0.86). The analysis results from MR Egger, weighted median, simple mode, and weighted mode were consistent with those of the random-effects IVW. There was no heterogeneity, horizontal pleiotropy. The MR analysis results were not influenced by any single SNP. Conclusion There is no causal relationship between appendectomy and colorectal cancer at the genetic level.

Key words: Appendectomy, Colorectal cancer, Mendelian randomization, Genetic level, Causal inference

CLC Number: 

  • R735.34
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