JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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ZHOU Nan-nan,ZHU Xing-lei,YE Lin,WANG Jian-chun   

  1. 1. Department of Health Care; 2. Department of Cardiology, Shandong Provincial Hospital,
  • Received:2006-02-10 Revised:1900-01-01 Online:2006-09-24 Published:2006-09-24
  • Contact: ZHOU Nan-nan

Abstract: To investigate the shortterm prognostic value of plasma Nterminal probrain natriuretic peptide (NTproBNP) on acute myocardial infarction. Method: A total of 132 subjects, including 30 healthy subjects and 102 patients with a first AMI were selected into the study. The plasma NTproBNP was measured at 48 to 96 hours after infarction. Total mortality and the risk for major adverse cardiac events (MACE, including death, recurrent MI, recurrent angina, heart failure, readmission for any reason) were analyzed. Results： Six months later, plasma NTproBNP was much higher in patients with AMI than that in health controls (326.1±193.4 pmol/L vs 73.5±58.3 pmol/L, P＜0.01 ). With the increasing of NTproBNP, the 6month mortality and the incidence of MACE had been raising. Multivariate logistic regression analyses showed that the plasma NTproBNP concentration predicted 6month mortality （r=0.943?7, P＜0.01）and incidence of MACE（r=0.607?2, P＜0.01）. Conclusion： The plasma NTproBNP level has relation with shortterm prognosis of AMI.

Key words: Natriuretic peptide, brain, Myocardial infarction, Prognosis

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