JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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ZHENG Guo-ling,CUI Gui-xiang,LI Yi-shao   

  • Received:2005-10-29 Revised:1900-01-01 Online:2006-08-24 Published:2006-08-24
  • Contact: ZHENG Guo-ling

Abstract: To study the clinical effects and safety of Huperzine A in treatment of vascular dementia (VaD). Methods: Eighty patients with VaD were randomly divided into Huperzine A therapy group and control group(each had 40 patients). Patients in both groups were given general drugs simultaneously, and patients in therapy group was treated with Huperzine A (0.2?mg/d) and in control group were treated with Piracetam. Before and 12, 24 weeks after treatment, the mini mental status examination (MMSE), clinical dementia rate (CDR) and activity of daily living (ADL, using Barthel Index) were measured by the same doctor. Results: After 24 weeks of treatment with Huperzine A, MMSE and ADL elevated (P＜0.01, P＜0.05 respectively), and CDR decreased (P＜0.05) significantly. These scores had no changes in control group. Conclusion: Huperzine A is an effective and safe drug in treatment of VaD.

Key words: Dementia, Vascular, Therapy, Huperzine A

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