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Stress in different intensity and duration effects the habitual expression of HSP70mRNA on the hippocampus of rats

SHAO Shu-hong, LI Zun-ling, JIANG Hong,WU Jiang，PAN Fang   

  1. 1.Department of Medical Psychology, Binzhou Medical College, Binzhou 256603, Shandong, China;2.Department of Biochemistry and Molecular Bioloy, Binzhou Medical College, Yantai 264003, Shandong, China;
  • Received:2005-09-14 Revised:1900-01-01 Online:2006-08-24 Published:2006-08-24

Abstract: To study the habitual expression of HSP70mRNA in hippocampus of rats by forcedswimming stress, and therefore to explore the effect of different intensity stress on the HSP70mRNA expression. Method: RTPCR was used to observe the changes of HSP70mRNA expression in hippocampus. Result: Repeated forced swimming in warm water resulted in expressive habituation, and an additive forced in 4?℃ water led to higher HSP70mRNA expression. Conclusion: Repeated stress may induce the habituation of the HSP70mRNA expression, and intense stress may reverse the habituation induced by repeated chronic stress.

Key words: Coercion, Swimming, Stress, Hippocampus, HSP70mRNA, Habituation, Rats, Wistar

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