Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (2): 41-46.doi: 10.6040/j.issn.1671-7554.0.2017.827

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Validity of SPECT/CT bone fusing imaging in the diagnosis of single bone metastasis of lung cancer

WANG Shanrong, DING Yueyun, ZHU Zongping, SHI Dedao, LIU Wanxia, ZHENG Feibo   

  1. Department of Nuclear Medicine, Qingdao Municipal Hospital Affiliated to Qingdao University, Qingdao 266071, Shandong, China
  • Published:2022-09-28

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Abstract: Objective To investigate the validity of single-photon emission computed tomography/computed tomography(SPECT/CT)bone fusing imaging in the diagnosis of single bone metastasis of lung cancer. Methods A retrospective study was conducted during June 2014 and June 2015 on 80 patients with confirmed lung cancer. All patients underwent 99Tc-methylene diphosphonate whole-body planar bone scintigraphy and had suspected bone metastasis. These patients were then further evaluated with SPECT/CT. The diagnostic results of the two methods were compared. The final results were confirmed with pathology findings(n=3), with more than 2 kinds of radiological imaging findings(n=45), and with 1-year follow-up(n=32). The diagnostic sensitivity, specificity, accuracy, positive and negative predictive values of the two methods were compared. The results were analyzed with SPSS 17.0 software and χ2 test. Results For bone scintigraphy and SPECT/CT fusion imaging, the specificity was 58.3% vs 91.7%(χ2=10.67, P<0.05), accuracy was 71.3% vs 90.0% (χ2=9.002, P<0.05), positive predictive value was 70.6% vs 92.9%(χ2=7.318, P<0.05), sensitivity was 81.8% vs 88.6%(χ2=0.81, P>0.05), and the negative predictive value was 72.4% vs 86.8%(χ2=0.81, P>0.05). Conclusion In the diagnosis of single bone metastasis of lung cancer, the SPECT/CT 山 东 大 学 学 报 (医 学 版)56卷2期 -王善容,等.SPECT/CT融合骨显像诊断肺癌单发骨转移的价值 \=- bone fusion imaging was superior to whole-body planar bone scintigraphy for its specificity, accuracy and positive predictive value. SPECT/CT fusion bone imaging is of great value in the diagnosis of single bone metastasis of lung cancer.

Key words: Single-photon emission computed tomography/computed tomography, Whole bone scintigraphy, Lung cancer, Bone metastasis, Diagnosis

CLC Number: 

  • R445
[1] Horger M, Bares R. The role of single-photon emission computed tomography/computed tomography in benign and malignant bone disease[J]. Semin Nucl Med, 2006, 36(4): 286.
[2] Utsunomiya D, Shiraishi S, Imuta M, et al. Added value of SPECT/CT fusion in assessing suspected bone metastasis: comparison with scintigraphy alone and nonfused scintigraphy and CT[J]. Radiology, 2006, 238(238): 264-271.
[3] Israel O, Keidar Z, Iosilevsky G, et al. The fusion of anatomic and physiologic imaging in the management of patients with cancer[J]. Semin Nucl Med, 2001, 31(3): 191.
[4] 张一秋, 石洪成, 顾宇参, 等. SPECT/CT骨显像对肺癌骨转移诊断的增益价值[J]. 中华核医学与分子影像杂志, 2011, 31(4): 219-222. ZHANG Yiqiu, SHI Hongcheng, GU Yushen, et al. The added diagnostic value of SPECT/CT imaging for bone metastases from lung cancer[J]. Chinese journal of Nuclear Medicine, 2011, 31(4): 219-222.
[5] 王新华, 赵艳萍, 陆海健,等. SPECT/CT显像诊断转移性骨肿瘤的临床意义[J]. 中华核医学与分子影像杂志, 2010, 30(2): 106-109. WANG Xinhua, ZHAO Yanping, LU Haijian, et al. Clinical value of SPECT/CT imaging in the diagnosis of bone metastasis[J]. Chinese Journal of Nuclear Medicine and Molecular Imaging, 2010, 30(2): 106-109.
[6] Sharma P, Kumar R, Singh H, et al. Indeterminate lesions on planar bone scintigraphy in lung cancer patients: SPECT, CT or SPECT-CT?[J]. Skeletal Radiol, 2012, 41(7): 843.
[7] Utsunomiya D, Shiraishi S, Imuta M, et al. Added value of SPECT/CT fusion in assessing suspected bone metastasis: comparison with scintigraphy alone and nonfused scintigraphy and CT[J]. Radiology, 2006, 238(1): 264-271.
[8] 肖壮伟, 李俊雄. 核素骨显像对骶髂关节、髋关节及脊柱关节病的诊断[J]. 中华核医学与分子影像杂志, 2000, 20(5): 211-212. XIAO Zhuangwei, LI Junxiong. Bone scintigraphic imaging of sacroiliac joint, hip joint and spondyloarthritis[J]. Chinese Journal of Nuclear Medicine and Molecular Imaging, 2000, 20(5): 211-212.
[9] 陈刚, 王铁, 杨燕芬,等. 全身骨显像在肺癌骨转移诊断中的应用及其影像特点[J]. 中国医学影像技术, 2009, 25(6): 1093-1095. CHEN Gang, WANG Tie, YANG Yanfen, et al. Application and characteristics of whole-body bone scanning in detecting bone metastases in lung cancer[J]. Chinese Journal of Medical Imaging Technology, 2009, 25(6): 1093-1095.
[10] Oliveira MB, Mello FC, Paschoal ME. The relationship between lung cancer histology and the clinicopathological characteristics of bone metastases[J]. Lung Cancer, 2016, 96(1): 19-24.
[11] 刘海荣, 于金明, 李岩, 等. ER、PR、C-erB-2与肺腺癌骨转移的相关性研究[J]. 山东大学学报(医学版), 2012, 50(4): 91-95. LIU Hairong, YU Jinming, LI Yan, et al. Study of the relationship between ER,PR,C-erB-2 and bone metastasis of lung adenocacinoma[J]. Journal of Shandong University(Health Sciences), 2012, 50(4): 91-95.
[12] 邢岩, 赵晋华, 汪太松, 等. 18F-FDG SPECT/CT诊断肺癌骨转移的价值: 与全身骨显像比较[J]. 中国医学计算机成像杂志, 2007, 13(3): 213-216. XING Yan, ZHAO Jinhua, WANG Taisong, et al. 18F-FDG SPECT/CT detection of bone metastases from lung cancer: comparison of 99Tcm-MDP whole- body bone scan[J].Chinese Computed Medical Imaging, 2007, 13(3): 213-216.
[13] 董科, 石洪成, 刘江, 等. SPECT/CT显像在肿瘤骨转移同一病灶动态随访中的价值[J]. 中华核医学与分子影像杂志, 2013, 33(3): 199-202. DONG Ke, SHI Hongcheng, LIU Jiang, et al. Value of SPECT/CT imaging for follow-up of bone metastases[J]. Chinese Journal of Nuclear Medicine and Molecular Imaging, 2013, 33(3): 199-202.
[14] Chen XL, Li Q, Cao L, et al. Diagnostic role of(99)Tc(m)-MDP SPECT/CT combined SPECT/MRI multi modality imaging for early and atypical bone metastases[J]. Int J Clin Exp Med, 2014, 7(12): 5336-5341.
[15] 常城, 谢文晖, 雷贝, 等. SPECT/CT融合显像对肺癌单发骨转移瘤的诊断价值[J]. 核技术, 2013, 36(9): 50-55. CHANG Cheng, XIE Wenhui, LEI Bei, et al. SPECT/CT fusion imaging for differential diagnosis of bone solitary metastases in patients with lung cancer[J]. Nuclear Techniques, 2013, 36(9): 50-55.
[16] 孟德刚, 孙晓光, 黄钢, 等. SPECT/CT骨显像在骨扫描诊断中的诊断价值[J]. 医学影像学杂志, 2011, 21(2): 274-279. MENG Degang, SUN Xiaoguang, HUANG Gang, et al. The diagnostic value of SPECT/CT in the bone scanning[J]. Journal of Medical Imaging, 2011, 21(2): 274-279.
[17] Zhao QT, Yang ZX, Yang L, et al. Diagnostic value of bone-specific alkaline phosphatase in lung carcinoma patients with bone metastases: a meta-analysis[J]. Int J Clin Exp Med, 2015, 8(10): 17271.
[18] Costelloe CM, Rohren EM, Madewell JE, et al. Imaging bone metastases in breast cancer: techniques and recommendations for diagnosis[J]. Lancet Oncol, 2009, 10(6): 606.
[19] Abikhzer G, Gourevich K, Kagna O, et al. Whole-body bone SPECT in breast cancer patients: the future bone scan protocol?[J]. Nucl Med Commun, 2016, 37(3): 247.
[20] Gnanasegaran G, Barwick T, Adamson K, et al. Multislice SPECT/CT in benign and malignant bone disease: when the ordinary turns into the extraordinary[J]. Semin Nucl Med, 2009, 39(6): 431-442.
[21] Sodee DB, Sodee AE, Bakale G. Synergistic value of single-photon emission computed tomography/computed tomography fusion to radioimmunoscintigraphic imaging of prostate cancer[J]. Semin Nucl Med, 2007, 37(1): 17-28.
[22] Peterson JJ, Kransdorf MJO, Connor MI. Diagnosis of occult bone metastases: positron emission tomography[J]. Clin Orthop Relat Res, 2003, 415(415 Suppl): 120.
[23] Eiber M, Takei T, Souvatzoglou M, et al. Performance of whole-body integrated 18F-FDG PET/MR in comparison to PET/CT for evaluation of malignant bone lesions[J]. J Nucl Med, 2014, 55(2): 191-197.
[24] Kwee TC, Takahara T, Ochiai R, et al. Diffusion-weighted whole-body imaging with background body signal suppression(DWIBS): features and potential applications in oncology[J]. Eur Radiol, 2008, 18(9): 1937.
[25] Layer G, Steudel A, Schüller H, et al. Magnetic resonance imaging to detect bone marrow metastases in the initial staging of small cell lung carcinoma and breast carcinoma[J]. Cancer, 1999, 85(4): 1004-1009.
[26] Yilmaz MH, Ozguroglu M, Mert D, et al. Diagnostic value of magnetic resonance imaging and scintigraphy in patients with metastatic breast cancer of the axial skeleton: a comparative study[J]. Med Oncol, 2008, 25(3): 257-263.
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