JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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LIN Ya-jie1,XIAO Wei-ling2   

  1. 1. Department of Medical Technology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;2. Department of Immunology, Weifang Medical College, Weifang 261042, Shandong, China
  • Received:2005-10-29 Revised:1900-01-01 Online:2006-07-24 Published:2006-07-24
  • Contact: LIN Ya-jie

Abstract: To evaluate the oxidative stress status and its clinical significance in patients with chronic hepatitis B. Methods: Total antioxidant response and malondialdehyde level were measured and oxidative stress index was calculated in 42 patients with chronic hepatitis B, 30 inactive carriers and 22 healthy controls. Results: Malondialdehyde (MDA) and oxidative stress index (OSI) were significantly higher in chronic hepatitis B patients than in inactive HbsAg carriers and controls（P＜0.05, P＜0.05，P＜0.01，P＜0.01）. Total antioxidant response was comparable in chronic hepatitis B subjects, inactive HbsAg carriers and controls (both P＞0.05). MDA and oxidative stress index were also comparable ininactive HBsAg carriers and controls (both P＞0.05). Serum alanine aminotransferase level was positively correlated with malondialdehyde concentration and oxidative stress index only in chronic hepatitis B subjects (r=0.61 and r=0.45, respectively), and there was no significant relationship between HBVDNA and oxidative stress. Conclusion: There are disturbances of oxidative stress and antioxidative

Key words: Hepatitis B, chronic, Oxidative stress, Malondialdehyde

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