Abstract: To observe the effect of bushenhuoxue complex on cytokine and anticoagulant factors in chronic cerebral circulation insufficiency model of subacute rats and to investigate the mechanism. Methods: Sixty healthy male Wistar rats were randomly divided into 6 groups: common， model， highdose treatment, lowdose treatment, and control group. Subacute aging model was induced by Dgalactose, and the bilateral arteria carotis communis was ligatured. The levels of SOD, MDA, T, Fib, ATIII, ET, TNF, and Pselectin in plasma were observed. Results: The morphology of brain was ischemic changed and had no cerbral infarction in model group; The level of SOD, NOS, T, ATIII dropped off（P＜0.01） d of ET, TNF, MDA, Fib, and Pselectin rised（P＜0.01in model group，whereas the former rised（P＜0.05）and the latter dropped off (P＜0.01，P＜0.05) in therapy group; The effect for them in highdose group was superior to lowdose group except for MDA and ET(P＜0.01，P＜0.05). Conclusion: Bushenhuoxue complex can correct the disequilibrium of cytokine and anticoagulant factors, which maybe by expanding the cerebral vessel, eliminating the free radical, inhibiting the inflammation and collecting the platelet.

Key words: Bushenhuoxue complex, Brain ischemia, Cytokines, Rats