Abstract: Based on evidence-based medicine, with the help of multidisciplinary collaborations such as surgery, anesthesia, nursing, and nutrition, enhanced recovery after surgery(ERAS)optimizes the clinical pathway for perioperative management, in order to reduce perioperative stress response and postoperative complications, relieve the physical and psychological traumatic stress of surgical patients, shorten hospital stay, and promote patients recovery. The optimized clinical pathway involves the whole process from pre-hospital, perioperative, to post-discharge, with an emphasis on serving patients. Postoperative pain is a major factor affecting the recovery of patients, which affects not only the length of hospital stays, but also patients long-term quality of life. Therefore, adequate pain relief is an important part of EARS, a prerequisite for early bed-out activities and early oral nutrition, and a meaningful way to reduce the surgical stress response. Multimodal analgesia(MMA)is currently recommended. This article focuses on postoperative pain management and multimodal analgesia, and reviews the current status of opioids, non-steroidal anti-inflammatory drugs(NSAIDS), other analgesic drugs, and analgesic techniques.

Key words: Enhanced recovery after surgery, Perioperative management, Multimodal analgesia, Postoperative pain, Painkiller