Abstract: o explore the relationship between the serum adipocytokins of adiponectin, TNFα and leptinin and pregnancy induced diabetes. Methods:Radioimmunoassay was used to detect the serum adiponectin, leptin and cpeptide ELISA was applied to detect TNFα levels in 50 women with pregnancy induced diabetes and 36 normal pregnant women, electrochemiluminescent immunoassays and pressure liquid chromatography(LPLC) were used to measure serum insulin and HbA1c respectively, and glucose oxidase method to measure the fasting glucose levels. Results: Compared with the normal pregnant women, adiponectin was significantly lowered ［(10.3±2.4)ug/ml vs（15.6±3.2）μg/ml］, TNFα was elevated ［(4.6±1.5)ng/ml vs（3.3±1.6）pg/ml］, and leptin significantly highered ［(15.3±3.8)ng/ml vs （ 10.3±2.1）ng/ml ］ in women with pregnancy induced diabetes; TNFα and leptin levels positively correlated with serum insulin levels, glucose levels, Cpeptide and HbA1c, whereas adiponectin negtively with the corresponding parameters. Conclusions: ⑴ Women with pregnancy induced diabetes have significantly lower adiponectin and higher TNFα and leptin in comparison to normal pregnant women;⑵ Elevated TNFα, leptin and decreased adiponectin may not simply reflect maternal insulin resistant state, but contribute to the impaired glucose metabolism during pregnancy and increase risk for the development of type 2 diabetes. Adipocytokins may forecast the risk of metabolism syndrome.

Key words: Diabetes, pregnancy-induced , Adipocytokins, Insulin resistanc