Journal of Shandong University (Health Sciences) ›› 2019, Vol. 57 ›› Issue (4): 42-46.doi: 10.6040/j.issn.1671-7554.0.2018.1341

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Magnetic resonance spectroscopy in patients with vascular cognitive impairment no dementia

ZHANG Xiaoqian, MENG Xiangshui, REN Qingguo, NAN Xiaomin, AN Panpan, SHUAI Xinyan, XIA Xiaona, WANG Xuan   

  1. Department of Radiology, Qilu Hospital of Shandong University, Qingdao 266035, Shandong, China
  • Published:2022-09-27

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Abstract: Objective To explore the relevance between metabolic changes in the critical parts of brain and vascular cognitive impairment no dementia(VCIND)by analyzing the metabolite ratios in VCIND patients using magnetic resonance spectroscopy(MRS). Methods A total of 38 VCIND patients(VCIND group)and 44 healthy controls(control group)were involved. The N-acetyl aspartate(NAA), choline(Cho), creatine(Cr), NAA/Cr and Cho/Cr in the frontal lobe, temporal lobe, thalamus, hippocampus, basal ganglia and cingulate gyrus in the two groups were measured with 3.0T MRS. The above parameters in dominant hemisphere of the two groups were compared and statistically analyred. Results Compared with the control group, the VCIND group had significantly reduced NAA in the temporal lobe, hippocampus, thalamus, and cingulate gyrus, and decreased NAA/Cr ratio in the frontal lobe, hippocampus, thalamus and cingulate gyrus (P<0.05). There were no statistical differences in Cho and Cho/Cr in different parts in the dominant hemisphere between two groups(P>0.05). There were no significant differences in all of the parameters between the dominant and non-dominant hemisphere in the VCIND group. Conclusion NAA and NAA/Cr are sensitive indicators to detect VCIND. VCIND patients have extensive cerebral metabolic disorder, but in the dominant hemisphere, the metabolic changes were associated with VCIND in the frontal lobe, temporal lobe, hippocampus, thalamus, and cingulate gyrus. 山 东 大 学 学 报 (医 学 版)57卷4期 -张晓倩,等.磁共振波谱成像对检测非痴呆型血管性认知障碍的探讨 \=-

Key words: Vascular cognitive impairment, Vascular cognitive impairment no dementia, Magnetic resonance spectroscopy, Magnetic resonance imaging, Metabolic disorder

CLC Number: 

  • R749
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