JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Clinical significance of expression of B7H4 in colon and rectal cancer tissues

SUN Yu-ping,LIU Jie, CUI Xia, ZHAO Dong， LIU Hui-ping， WANG Yun-shan   

  1. Department of Tumor Treatment, Jinan Central Hospital, School of Clinical Medicine, Shandong University, Jinan 250013, Shandong, China
  • Received:2005-02-14 Revised:1900-01-01 Published:2006-06-25
  • Contact: SUN Yu-ping

Abstract: To investigate the role of B7H4 in the development of colon and rectal cancer(CRC). Method: The expression of B7H4 in 40 excised colon and rectal tumors was evaluated immunohistochemiscally. Results: B7H4 was high expressed (80.0%)in colon and rectal cancer. No relationship was found between the expression of B7H4 and sex, age, histology type, pathology stage, cell differentiation, or lympha metastasis. However, significantly fewer TILs was identified in B7H4positive tumor specimens than in B7H4negative tumor specimens. Conclusion: ①B7H4 may be a new marker of diagnosis for colon and rectal cancer;② These results suggest that the expression of B7H4 on tumor tissue may contribute to negative regulatory immunue responses against TILs in colon and rectal cancer. The blockade of B7H4 in colon and rectal cancer might be one strategy to pursue for future immunotherapy in colon and rectal cancer.

Key words: B7-H4, TILs, Colorectal neoplasms, Immunohistochemistry

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