Journal of Shandong University (Health Sciences) ›› 2019, Vol. 57 ›› Issue (2): 11-15.doi: 10.6040/j.issn.1671-7554.0.2018.1382

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Effects of climacteric and menopausal hormone therapy on immune system

SHI Yuhua1, ZHENG Qingmei2   

  1. 1. Center for Reproductive Medicine, Shandong University;
    National Research Center for Assisted Reproductive Technology 〓山〓东〓大〓学〓学〓报〓(医〓学〓版)57卷2期〓-石玉华, 等.更年期及绝经激素治疗对免疫系统的影响〓\=-and Reproductive Genetics;
    The Key Laboratory of Reproductive Endocrinology(Shandong University), Ministry of Education;
    Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Jinan 250001, Shandong, China;
    2. Department of Obstetrics and Gynecology, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong, China
  • Published:2022-09-27

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Abstract: Ovarian dysfunction is a prominent manifestation of female aging. Women will experience menstrual changes until menopause, accompanied by a variety of menopausal-related symptoms. Menopause not only has a persistent adverse effect on cardiovascular, skeletal and cognitive functions, but also leads to various changes in the immune system. Studies have shown that estrogen can regulate humoral and cellular immunity, and the imbalance of estrogen content and function can lead to immune dysfunction. Menopausal hormone therapy can not only improve menopausal-related symptoms, but also improve ovarian hormone deficiency-related immune aging, enhance the immune function of normal aging women, and improve the quality of life of menopausal women.

Key words: Climacteric, Menopause, Menopausal hormone therapy, Immune system, Effect

CLC Number: 

  • R711.75
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