JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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YAN Jun-hao, CHEN Zi-jiang, LI Yuan, HU Jing-mei, GAO Shan-shan   

  1. Reproductive Medical Center, Shandong Provincial Hospital， Shandong University，Jinan 250021， Shandong， China
  • Received:2006-04-29 Revised:1900-01-01 Online:2006-06-24 Published:2006-06-24
  • Contact: YAN Jun-hao

Abstract: To examine the sex chromosomal aneuploid of embryos from monopronucleus zygotes derived from invitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Methods: A total of 111 embryos from monopronucleus (1PN), zygotes derived from IVF and ICSI were examined by using fluorescent in situ hybridization (FISH) technique with X, Y dual color centromere probes. Result: The total ratio of fixation was 92.80%, and of hybridization was 95.15%. In embryos from monopronucleus zygotes after IVF, the ratios of sex chromosome disome, monosomic and mosaic were 54.35％,23.91％and 21.74％； in embryos from monopronucleus zygotes after ICSI, they were 34.62％,34.62％and 30.77％. Conclusion: Embryos from monopronucleus zygotes after IVF or ICSI are not suggested to be transferred for the aneuploid ratio. Sex chromosome disome ratio of embryos from monopronucleus zygotes after IVF is significantly higher than that after ICSI.

Key words: Aneuploid, In situ hybridization, fluorescent, Embryo, Monopronucleus zygotes

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