Abstract: To investigate the factors associated with the presence of spontaneous bacterial peritonitis (SBP) in patients with hepatitis B virus(HBV)related liver cirrhosis. Methods568 patients with HBV-related liver cirrhosis hospitalized in Jinan Infectious Disease Hospital were investigated. Demographic data and biochemical parameters were analyzed by using SPSS software. ResultsThe prevalence rate of SBP was 40.1% in the cohort studied.　Univariate analysis showed that the TBIL, PT and TG levels, and the thickness of the spleen were higher, however, the ALT, ALB, GGT, CH and PLT levels were lower in the SBP group than those in the nonSBP group. There were no statistical differences in gender, alcohol abuse, HBeAg, presence of diabetes, age, AST, AFP, AKP and diameter of portal vein levels between the two groups. After adjustment of gender, age, alcohol abuse, AKP abnormal, PLT abnormal, HBeAg, ALT, AST and diameter of the portal vein, multiple regression analysis showed that TBIL＞50μmol/L, ALB＜35g/L, CH＜2.6mmol/L and splenomegaly were independent risk factors of the presence of SBP. ConclusionsIncreased bilirubin, decreased albumin and cholesterol and splenomegaly are independent risk factors of the presence of SBP. Impaired liver function and splenomegaly, but not enlargement of portal vein diameter, are associated with the presence of SBP in HBV-related cirrhosis.

Key words: Hepatitis B, Liver cirrhosis, Peritonitis