JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (8): 72-77.doi: 10.6040/j.issn.1671-7554.0.2016.355

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Correlation between lymphocyte-to-monocyte ratio in peripheral blood and prognosis of malignant pleural mesothelioma

WANG Wen, LIU Yao, LONG Fei, MA Weixia, SU Lili   

  1. Department of Respiratory, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250012, Shandong, China
  • Received:2016-04-01 Online:2016-08-10 Published:2016-08-10

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Abstract: Objective To explore the correlation between lymphocyte-to-monocyte ratio(LMR)in peripheral blood and prognosis of malignant pleural mesothelioma(MPM). Methods Clinicopathological data of 85 patients with MPM were retrospectively analyzed. According to the LMR in peripheral blood, the patients were divided into two groups: high LMR group(n=27)and low LMR group(n=58). The clinicopathological data and overall survival of the two groups were compared. The correlation between the clinicopathological data and the overall survival was analyzed with Cox regression model. Results Significant differences were observed between the two groups in gender, performance status(PS)score, absolute lymphocyte count and absolute monocyte count(P<0.05). The median overall survival of patients with high LMR was significantly longer than that of patients with low LMR(27 months vs 9 months, P<0.001). Of patients with various histological types and tumor stages, the median overall survival of patients with high LMR was significantly longer than that of patients with low LMR. Multivariate analysis showed that LMR was an independent prognostic factor associated with prognosis of MPM(HR: 0.277; 95% CI: 0.142-0.538; P<0.001). Conclusion LMR in peripheral blood is a biological marker for the prognosis of MPM.

Key words: Thoracoscopy, Lymphocyte-to-monocyte ratio, Malignant pleural mesothelioma, Prognosis, Overall survival

CLC Number: 

  • R734.3
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