Abstract: Objective To explore the timing of percutaneous coronary intervention(PCI)for non-infarct-related artery(Non-IRA)in patients with acute myocardial infarction(AMI)and multi-vessel disease(MVD). Methods A total of 357 cases of AMI and MVD were divided into 5 groups according to whether and when they underwent PCI for Non-IRA: control group(n=117, who underwent PCI for culprit vessel only), MV-PCI group(n=32, who underwent PCI simultaneously for both culprit vessel and Non-IRA), 0-7d group(n=28, who underwent PCI for Non-IRA within 7 day); 8-30 d group(n=84, who underwent PCI for Non-IRA within 8-30 days), 31-60 d group(n=96, who underwent PCI for Non-IRA within 31-60 days). All patients were followed up for 2 years. Clinical characteristics, data collected during surgery and major adverse cardiac event(MACE)were analyzed. Results The incidence of in-hospital MACE was the highest in the MV-PCI group(18.8%), the lowest in the control group(3.4%), and the second lowest in the 31-60 d group(P=0.02). The incidence of follow-up MACE was the highest in the control group(59.8%)(P<0.01), and the cumulative rate of MACE was the lowest in the 31-60 d group(18.80%)(P<0.01). Conclusion PCI of Non-IRA can improve the prognosis. Emergency PCI for simultaneous culprit vessel and Non-IRA is risky. Its advisable to choose PCI for Non-IRA within 31-60 days after AMI.

Key words: Prognosis, Myocardial infarction, Multivessel disease, Non-infarct-related artery, Percutaneous coronary