JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (5): 88-91.doi: 10.6040/j.issn.1671-7554.0.2015.927

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Changes of carotid artery structure and function in children with primary nephrotic syndrome

WANG Dan1, QI Hengtao2, SUN Shuzhen1   

  1. 1. Department of Pediatric Nephrology and Rheumatism and Immunology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China;
    2. Shandong Medical Imaging Research Institute, Jinan 250021, Shandong, China
  • Received:2015-09-29 Online:2016-05-16 Published:2016-05-16

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Abstract: Objective To explore the changes of carotid artery structure and function as early indicators of atherosclerosis(AS)in children with primary nephrotic syndrome(PNS). Methods Between Feb.2013 to Dec. 2014, 122 children with PNS(82 in active state, 40 in remission state), and 40 healthy controls were enrolled. Carotid ultrasonography, serum albumin, serum lipid and 24-hour urine protein quantity of all subjects were determined. The results collected were analyzed with variance analysis, Spearsman rank correlation test, and multiple stepwise regression analysis. Results Compared with the controls, patients in active state had significantly higher carotid intima-media thickness(cIMT), carotid stiffness coefficient(β), mean wall cross-sectional area(WCSA), but lower carotid artery movement(△D)(all P<0.05). There was a positive correlation between cIMT and disease relapse number(r=0.29, P<0.01). Multiple stepwise regression analysis showed that cIMT was associated with total cholesterol(TC)and lipoprotein(a)［Lp(a)］(R2=0.22, β=0.01, P<0.01; β=0.03, P=0.02). Conclusion Carotid artery structure and function are changed in children with PNS, and the risks for AS are increased. cIMT can be used to predict the potential risk of AS, which is associated with lipid metabolism disorder and disease relapse.

Key words: Primary nephrotic syndrome, Atherosclerosis, Carotid intima-media thickness, Lipid disorders

CLC Number: 

  • R729.6
[1] 中华医学会儿科学分会肾脏病学组. 儿童常见肾脏疾病诊治循证指南(一): 激素敏感、复发/依赖肾病综合征诊治循证指南(试行)[J]. 中华儿科杂志, 2009, 47(3): 167-169.
[2] Caglar K, Yilmaz MI, Sonmez A, et al. ADMA, proteinuria, and insulin resistance in non-diabetic stage I chronic kidney disease[J]. Kidney Int, 2006, 70(4): 781-787.
[3] Vladimirova-Kitova L, Deneva T, Marinov B. Predictors of the intima-media thickness of carotic artery in asymptomatic newly detected severe hypercholesterolemic patients[J]. Clin Physiol Funct Imaging, 2010, 30(4): 250-259.
[4] 卢强, 王正荣, 黄景, 等. 血管回声跟踪技术对颈动脉斑块者颈动脉弹性功能的定量检测[J]. 中国动脉硬化杂志, 2007, 5(15): 374-376. LU Qing, WANG Zhengrong, HUANG Jing, et al. Quantitative evaluation of carotid elasticity in patients with carotid plaque by E-tracking technique[J]. Chin J Arteroscler, 2007, 5(15): 374-376.
[5] Lisowska A, Knapp M, Bolińska S, et al. The importance of intima-media thickness(IMT)measurements in monitoring of atherosclerosis progress after myocardial infarction[J]. Adv Med Sci, 2012, 57(1): 112-117.
[6] Molinari F, Rajendra Acharya U, Zeng G, et al. Completely automated robust edge snapper for carotid ultrasound IMT measurement on a multi-institutional database of 300 images[J]. Med Biol Eng Comput, 2011, 49(8): 935-945.
[7] Candan C, Canpolat N, Gökalp S, et al. Subclinical cardiovascular disease and its association with risk factors in children with steroid-resistant nephrotic syndrome[J]. Pediatr Nephrol, 2014, 29(1): 95-102.
[8] Hooman N, Isa-Tafreshi R, Otukesh H, et al. Carotid artery function in children with idiopathic nephrotic syndrome[J]. Nefrologia, 2013, 33(5): 650-656.
[9] Lv Y, Hou X, Ti Y, et al. Associations of CXCL16/CXCR6 with carotid atherosclerosis in patients with metabolic syndrome[J]. Clin Nutr, 2013, 32(5): 849-854.
[10] Azarkhish K, Mahmoudi K, Mohammadifar M, et al. Mean right and left carotid intima-media thickness measures in cases with/without coronary artery disease[J]. Acta Med Iran, 2014, 52(12): 884-888.
[11] 裴芳, 李小鹰, 方颖, 等. 老年原发性高血压左心室肥厚患者心肾微动脉的病理特征[J]. 中华心血管病杂志, 2008, 10(36): 872-877. PEI Fang, LI Xiaoying, FANG Ying, et al. Cardiac and renal arteriolar pathological changes in the autopsied elderly hypertrophy[J]. Chin J Cardiol, 2008, 10(36): 872-877.
[12] 梁虹, 车国英,苏雁欣,等. 尿毒症患者颈总动脉弹性与左心室舒张功能关系的超声研究[J]. 实用医学杂志, 2013, 14(29): 2317-2318.
[13] 张辉, 赵素玲, 李鹏, 等. 超声回声跟踪技术评价不伴危险因素的糖耐量减低患者颈动脉僵硬度改变[J]. 中国医学影像技术, 2012, 28(2): 282-285. ZHANG Hui, ZHAO Suling, LI Peng, et al. Ultrasound echo-tracking in assessing carotid artery stiffness of impaired glucose tolerance patients without risk factors[J]. Chin J Med Imaging Technol, 2012, 28(2): 282-285.
[14] Peters SA, Bots ML. Carotid intima-media thickness studies: study design and data analysis[J]. J Stroke, 2013, 15(1): 38-48.
[15] 张碧丽, 王健. 肾病综合征患儿的脂代谢紊乱[J]. 中华实用儿科临床杂志, 2013, 5(28): 398-400.
[16] 周长林. 肾病综合征脂质代谢紊乱研究进展[J]. 中国综合临床, 2003, 10(19): 869-870.
[17] Mérouani A, Lévy E, Mongeau JG, et al. Hyperlipidemic profiles during remission in childhood idiopathic nephrotic syndrome[J]. Clin Biochem, 2003, 36(7): 571-574.
[18] Knia(·overz)ewska MH, Obuchowicz AK, Wielkoszyński T, et al. Atherosclerosis risk factors in young patients formerly treated for idiopathic nephrotic syndrome[J]. Pediatr Nephrol, 2009, 24(3): 549-554.
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